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<p>Новая страница: «Elastin precursor (Tropoelastin) ==Publications== {{medline-entry |title=Curcumin enhances the production of major structural components of elastic fibers, elas...»</p> <p><b>Новая страница</b></p><div>Elastin precursor (Tropoelastin)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25333322<br /> |abstract=Curcumin is the major component of the yellow extract derived from the rhizome of the Curcuma longa, which is also a main bioactive polyphenol and has been generally used as a spice, food additive, and herbal medicine. In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing [[ELN]] and FBN1 promoters&#039; activities. With 2 μM curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively. Therefore, our results demonstrated that curcumin may be used as a functional compound and applied to drugs, foods, and cosmetics in the future.<br /> |mesh-terms=* Aging<br /> * Cell Line<br /> * Curcumin<br /> * Elastic Tissue<br /> * Elastin<br /> * Fibrillin-1<br /> * Fibrillins<br /> * Fibroblasts<br /> * Humans<br /> * Microfilament Proteins<br /> * Promoter Regions, Genetic<br /> * RNA, Messenger<br /> * Tropoelastin<br /> |keywords=* curcumin<br /> * elastin<br /> * fibrillin-1<br /> * fibroblast cells<br /> * promoter activity<br /> |full-text-url=https://sci-hub.do/10.1080/09168451.2014.972324<br /> }}</div>

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