https://transhumanist.ru/index.php?action=history&feed=atom&title=ELK1 2026-05-15T17:25:41Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ELK1&diff=4664&oldid=prev 2021-04-29T19:28:47Z

<p>Новая страница: «ETS domain-containing protein Elk-1 ==Publications== {{medline-entry |title=Tocotrienol-rich fraction prevents cellular aging by modulating cell proliferation s...»</p> <p><b>Новая страница</b></p><div>ETS domain-containing protein Elk-1<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Tocotrienol-rich fraction prevents cellular aging by modulating cell proliferation signaling pathways.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25945449<br /> |abstract=Vitamin E has been suggested as nutritional intervention for the prevention of degenerative and age-related diseases. In this study, we aimed to elucidate the underlying mechanism of tocotrienol-rich fraction (TRF) in delaying cellular aging by targeting the proliferation signaling pathways in human diploid fibroblasts (HDFs). Tocotrienol-rich fraction was used to treat different stages of cellular aging of primary human diploid fibroblasts viz. young (passage 6), pre-senescent (passage 15) and senescent (passage 30). Several selected targets involved in the downstream of PI3K/AKT and RAF/MEK/ERK pathways were compared in total RNA and protein. Different transcriptional profiles were observed in young, pre-senescent and senescent HDFs, in which cellular aging increased AKT, [[FOXO3]], [[CDKN1A]] and RSK1 mRNA expression level, but decreased [[ELK1]], [[FOS]] and [[SIRT1]] mRNA expression level. With tocotrienol-rich fraction treatment, gene expression of AKT, [[FOXO3]], ERK and RSK1 mRNA was decreased in senescent cells, but not in young cells. The three down-regulated mRNA in cellular aging, [[ELK1]], [[FOS]] and [[SIRT1]], were increased with tocotrienol-rich fraction treatment. Expression of [[FOXO3]] and P21Cip1 proteins showed up-regulation in senescent cells but tocotrienol-rich fraction only decreased P21Cip1 protein expression in senescent cells. Tocotrienol-rich fraction exerts gene modulating properties that might be responsible in promoting cell cycle progression during cellular aging.<br /> |mesh-terms=* Antioxidants<br /> * Cell Proliferation<br /> * Cells, Cultured<br /> * Cellular Senescence<br /> * Diploidy<br /> * Fibroblasts<br /> * Humans<br /> * Tocotrienols<br /> * Vitamin E<br /> |keywords=* Cellular aging<br /> * Gene expression<br /> * Human diploid fibroblasts<br /> * Tocotrienol-rich fraction<br /> * Vitamin E<br /> |full-text-url=https://sci-hub.do/10.7417/CT.2015.1825<br /> }}</div>

OdysseusBot