https://transhumanist.ru/index.php?action=history&feed=atom&title=EHMT1 2026-07-31T12:56:13Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=EHMT1&diff=4128&oldid=prev 2021-04-29T19:02:10Z

<p>Новая страница: «Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H...»</p> <p><b>Новая страница</b></p><div>Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) [EUHMTASE1] [GLP] [KIAA1876] [KMT1D]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Two conserved epigenetic regulators prevent healthy ageing.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32103178<br /> |abstract=It has long been assumed that lifespan and healthspan correlate strongly, yet the two can be clearly dissociated . Although there has been a global increase in human life expectancy, increasing longevity is rarely accompanied by an extended healthspan . Thus, understanding the origin of healthy behaviours in old people remains an important and challenging task. Here we report a conserved epigenetic mechanism underlying healthy ageing. Through genome-wide RNA-interference-based screening of genes that regulate behavioural deterioration in ageing Caenorhabditis elegans, we identify 59 genes as potential modulators of the rate of age-related behavioural deterioration. Among these modulators, we found that a neuronal epigenetic reader, BAZ-2, and a neuronal histone 3 lysine 9 methyltransferase, [[SET]]-6, accelerate behavioural deterioration in C. elegans by reducing mitochondrial function, repressing the expression of nuclear-encoded mitochondrial proteins. This mechanism is conserved in cultured mouse neurons and human cells. Examination of human databases shows that expression of the human orthologues of these C. elegans regulators, [[BAZ2B]] and [[EHMT1]], in the frontal cortex increases with age and correlates positively with the progression of Alzheimer&#039;s disease. Furthermore, ablation of Baz2b, the mouse orthologue of BAZ-2, attenuates age-dependent body-weight gain and prevents cognitive decline in ageing mice. Thus our genome-wide RNA-interference screen in C. elegans has unravelled conserved epigenetic negative regulators of ageing, suggesting possible ways to achieve healthy ageing.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Caenorhabditis elegans<br /> * Caenorhabditis elegans Proteins<br /> * Cognition<br /> * Cognitive Dysfunction<br /> * Epigenesis, Genetic<br /> * Healthy Aging<br /> * Histone-Lysine N-Methyltransferase<br /> * Histones<br /> * Humans<br /> * Longevity<br /> * Lysine<br /> * Male<br /> * Memory<br /> * Methylation<br /> * Mice<br /> * Mitochondria<br /> * Neurons<br /> * Proteins<br /> * RNA Interference<br /> * Spatial Learning<br /> * Transcription Factors, General<br /> <br /> |full-text-url=https://sci-hub.do/10.1038/s41586-020-2037-y<br /> }}</div>

OdysseusBot