https://transhumanist.ru/index.php?action=history&feed=atom&title=EFEMP1 2026-04-08T01:27:37Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=EFEMP1&diff=6454&oldid=prev 2021-05-12T15:31:23Z

<p>Новая страница: «EGF-containing fibulin-like extracellular matrix protein 1 precursor (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3) [FBLN3] [FBNL] ==...»</p> <p><b>Новая страница</b></p><div>EGF-containing fibulin-like extracellular matrix protein 1 precursor (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3) [FBLN3] [FBNL]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=A novel age-related venous amyloidosis derived from [[EGF]]-containing fibulin-like extracellular matrix protein 1.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30565683<br /> |abstract=Most intractable tissue-degenerative disorders share a common pathogenic condition, so-called proteinopathy. Amyloid-related disorders are the most common proteinopathies and are characterized by amyloid fibril deposits in the brain or other organs. Aging is generally associated with the development of these amyloid-related disorders, but we still do not fully understand how functional proteins become pathogenic amyloid deposits during the human aging process. We identified a novel amyloidogenic protein, named epidermal growth factor-containing fibulin-like extracellular matrix protein 1 ([[EFEMP1]]), in massive venous amyloid deposits in specimens that we obtained from an autopsied patient who died of gastrointestinal bleeding. Our postmortem analyses of additional patients indicate that [[EFEMP1]] amyloid deposits frequently developed in systemic venous walls of elderly people. [[EFEMP1]] was highly expressed in veins, and aging enhanced venous [[EFEMP1]] expression. In addition, biochemical analyses indicated that these venous amyloid deposits consisted of C-terminal regions of [[EFEMP1]]. In vitro studies showed that C-terminal regions formed amyloid fibrils, which inhibited venous tube formation and cell viability. [[EFEMP1]] thus caused a novel age-related venous amyloid-related disorder frequently found in the elderly population. Understanding [[EFEMP1]] amyloid formation provides new insights into amyloid-related disorders occurring during the aging process. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley</div>

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