https://transhumanist.ru/index.php?action=history&feed=atom&title=EFCAB5EFCAB5 - История изменений2026-04-20T11:16:10ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=EFCAB5&diff=6453&oldid=prevOdysseusBot: Новая страница: «calcium-binding domain-containing protein 5 ==Publications== {{medline-entry |title=Genetic architecture of epigenetic and neuronal ageing rates in human brain...»2021-05-12T15:31:20Z<p>Новая страница: «calcium-binding domain-containing protein 5 ==Publications== {{medline-entry |title=Genetic architecture of epigenetic and neuronal ageing rates in human brain...»</p>
<p><b>Новая страница</b></p><div>calcium-binding domain-containing protein 5<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28516910<br />
|abstract=Identifying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 individuals, we carry out a GWAS of two DNA methylation-based biomarkers of brain age: the epigenetic ageing rate and estimated proportion of neurons. Locus 17q11.2 is significantly associated (P=4.5 × 10 ) with the ageing rate across five brain regions and harbours a cis-expression quantitative trait locus for [[EFCAB5]] (P=3.4 × 10 ). Locus 1p36.12 is significantly associated (P=2.2 × 10 ) with epigenetic ageing of the prefrontal cortex, independent of the proportion of neurons. Our GWAS of the proportion of neurons identified two genome-wide significant loci (10q26 and 12p13.31) and resulted in a gene set that overlaps significantly with sets found by GWAS of age-related macular degeneration (P=1.4 × 10 ), ulcerative colitis (P<1.0 × 10 ), type 2 diabetes (P=2.8 × 10 ), hip/waist circumference in men (P=1.1 × 10 ), schizophrenia (P=1.6 × 10 ), cognitive decline (P=5.3 × 10 ) and Parkinson's disease (P=8.6 × 10 ).<br />
|mesh-terms=* Adolescent<br />
* Adult<br />
* Aged<br />
* Aged, 80 and over<br />
* Aging<br />
* Brain<br />
* Brain Mapping<br />
* Calcium-Binding Proteins<br />
* Child<br />
* Child, Preschool<br />
* Cognitive Dysfunction<br />
* DNA Methylation<br />
* Epigenesis, Genetic<br />
* Female<br />
* Genome, Human<br />
* Genome-Wide Association Study<br />
* Humans<br />
* Infant<br />
* Male<br />
* Middle Aged<br />
* Nerve Tissue Proteins<br />
* Neurodegenerative Diseases<br />
* Neurons<br />
* Quantitative Trait Loci<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454371<br />
}}</div>OdysseusBot