https://transhumanist.ru/index.php?action=history&feed=atom&title=EDNRAEDNRA - История изменений2026-04-05T07:20:55ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=EDNRA&diff=4575&oldid=prevOdysseusBot: Новая страница: «Endothelin-1 receptor precursor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) [ETA] [ETRA] ==Publications== {{medline-entry |title=Variation in genes in...»2021-04-29T19:24:46Z<p>Новая страница: «Endothelin-1 receptor precursor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) [ETA] [ETRA] ==Publications== {{medline-entry |title=Variation in genes in...»</p>
<p><b>Новая страница</b></p><div>Endothelin-1 receptor precursor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) [ETA] [ETRA]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23336501<br />
|abstract=Indirect evidences by blockade of the endothelin receptors have suggested a role of endothelin in endothelium-dependent vasodilation. This study aimed to investigate whether circulating levels of endotehlin-1 or genetic variations in genes in the endothelin pathway were related to endothelium-dependent vasodilation. In 1016 seventy-year-old participants of the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study (52% women), we measured endothelium-dependent vasodilation using the invasive forearm technique with acetylcholine given in the brachial artery (EDV) and the brachial artery ultrasound technique with measurement of flow-mediated dilatation (FMD). Plasma endothelin-1 levels were measured and 60 SNPs in genes in the endothelin pathway (ECE1, [[EDN1]], [[EDNRA]], [[EDNRB]]) were genotyped. No significant associations were found between circulating endothelin levels and EDV or FMD. No single genotype was related to EDV or FMD following adjustment for multiple testing, but a genotype score for 3 SNPs (rs11618266 in [[EDNRB]], rs17675063 in [[EDNRA]], rs3026868 in ECE1) was significantly related to EDV (beta coefficient 0.070, 95% CI 0.025-0.12, P = 0.002) when adjusting for gender, systolic blood pressure, HDL and LDL cholesterol, serum triglycerides, BMI, diabetes, smoking, antihypertensive medication or statins and [[CRP]]. This score was also related to nitroprusside-induced vasodilation in the forearm. A combination of genotypes in the endothelin pathway was related to both endothelium-dependent and endothelium-independent vasodilation in forearm resistance vessels, but not in the brachial artery in an elderly population, giving evidence for a role of the endothelin system in resistance vessel reactivity independent of major cardiovascular risk factors.<br />
|mesh-terms=* Age Factors<br />
* Aged<br />
* Aging<br />
* Aspartic Acid Endopeptidases<br />
* Brachial Artery<br />
* Endothelin-1<br />
* Endothelin-Converting Enzymes<br />
* Endothelium, Vascular<br />
* Female<br />
* Forearm<br />
* Genotype<br />
* Humans<br />
* Infusions, Intra-Arterial<br />
* Linear Models<br />
* Male<br />
* Metalloendopeptidases<br />
* Phenotype<br />
* Polymorphism, Single Nucleotide<br />
* Prospective Studies<br />
* Receptor, Endothelin A<br />
* Receptor, Endothelin B<br />
* Regional Blood Flow<br />
* Sweden<br />
* Ultrasonography<br />
* Vasodilation<br />
* Vasodilator Agents<br />
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|full-text-url=https://sci-hub.do/10.1111/apha.12068<br />
}}</div>OdysseusBot