https://transhumanist.ru/index.php?action=history&feed=atom&title=ECM1 2026-06-07T07:17:52Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ECM1&diff=6441&oldid=prev 2021-05-12T15:30:46Z

<p>Новая страница: «Extracellular matrix protein 1 precursor (Secretory component p85) ==Publications== {{medline-entry |title=Novel role of extracellular matrix protein 1 ([[ECM1]...»</p> <p><b>Новая страница</b></p><div>Extracellular matrix protein 1 precursor (Secretory component p85)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Novel role of extracellular matrix protein 1 ([[ECM1]]) in cardiac aging and myocardial infarction.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30789914<br /> |abstract=The prevalence of heart failure increases in the aging population and following myocardial infarction (MI), yet the extracellular matrix (ECM) remodeling underpinning the development of aging- and MI-associated cardiac fibrosis remains poorly understood. A link between inflammation and fibrosis in the heart has long been appreciated, but has mechanistically remained undefined. We investigated the expression of a novel protein, extracellular matrix protein 1 ([[ECM1]]) in the aging and infarcted heart. Young adult (3-month old) and aging (18-month old) C57BL/6 mice were assessed. Young mice were subjected to left anterior descending artery-ligation to induce MI, or transverse aortic constriction (TAC) surgery to induce pressure-overload cardiomyopathy. Left ventricle (LV) tissue was collected early and late post-MI/TAC. Bone marrow cells (BMCs) were isolated from young healthy mice, and subject to flow cytometry. Human cardiac fibroblast (CFb), myocyte, and coronary artery endothelial</div>

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