https://transhumanist.ru/index.php?action=history&feed=atom&title=DUSP8 2026-06-28T16:02:05Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=DUSP8&diff=3967&oldid=prev 2021-04-29T18:54:06Z

<p>Новая страница: «Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) [C11orf81] [VH5] ==Publications== {{medline-entr...»</p> <p><b>Новая страница</b></p><div>Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) [C11orf81] [VH5]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400088<br /> |abstract=Intracerebral haemorrhage (ICH) is a severe neurological disorder caused by bleeding within the brain tissue. Inflammation has been implicated in ICH pathogenesis and is a potential therapeutic target for ICH. Haemin, an activator of haem oxygenase-1 (HO-1), rapidly increases HO-1 protein expression and activity and has been shown to distinctly affect anti-inflammatory functions after central nervous system (CNS) injury. However, less is known about the mechanisms that underlie the anti-inflammatory effects of haemin in aged rats post-ICH. Here, we performed microarray analysis to identify miRNAs that respond strongly to HO-1 regulation in ICH rats and found that miR-21-5p induced the most significant change. Using Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and Gene Ontology (GO) analysis, we focused on dual-specificity phosphatase 8 ([[DUSP8]]) from the predicted miR-21-5p targets. Luciferase reporter assays confirmed that miR-21-5p bound directly to [[DUSP8]]. MiR-21-5p upregulation in vitro downregulated [[DUSP8]] expression. Importantly, intracerebroventricularly injecting antagomir for miR-21-5p (A-miR-21-5p), which was used to inhibit miR-21-5p in aged ICH rats, significantly reduced the neurological defects, repaired cognitive impairment, alleviated blood-brain barrier (BBB) permeability, inhibited neuronal apoptosis posthaemorrhage and accelerated haematoma absorption. In addition, serum miR-21-5p levels were notably elevated in patients relative to healthy individuals and were correlated with National Institutes of Health Stroke Scale (NIHSS) scores and clinical outcomes. In summary, A-miR-21-5p increased HO-1 expression in cerebral haematomas, thus eliciting the [[DUSP8]]-modulated perifocal neuroprotective effect of haemin. MiR-21-5p with haemin therapy may be a potential therapy post-ICH.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Antagomirs<br /> * Anti-Inflammatory Agents<br /> * Cells, Cultured<br /> * Cerebral Hemorrhage<br /> * Dual-Specificity Phosphatases<br /> * HEK293 Cells<br /> * Heme Oxygenase-1<br /> * Hemin<br /> * Humans<br /> * Male<br /> * MicroRNAs<br /> * Rats<br /> * Rats, Sprague-Dawley<br /> * Signal Transduction<br /> |keywords=* aging<br /> * dual-specificity phosphatase 8<br /> * haem oxygenase-1<br /> * intracerebral haemorrhage<br /> * microRNA<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826124<br /> }}</div>

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