https://transhumanist.ru/index.php?action=history&feed=atom&title=DUSP4 2026-06-09T01:47:47Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=DUSP4&diff=5659&oldid=prev 2021-05-12T13:54:09Z

<p>Новая страница: «Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (M...»</p> <p><b>Новая страница</b></p><div>Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) [MKP2] [VH2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22434910<br /> |abstract=T cell-dependent B-cell responses decline with age, suggesting defective [[CD4]] T-cell function. [[CD4]] memory T cells from individuals older than 65 y displayed increased and sustained transcription of the dual-specific phosphatase 4 ([[DUSP4]]) that shortened expression of [[CD4]]0-ligand ([[CD4]]0L) and inducible T-cell costimulator ([[ICOS]]) (both P &lt; 0.001) and decreased production of IL-4, IL-17A, and IL-21 (all P &lt; 0.001) after in vitro activation. In vivo after influenza vaccination, activated [[CD4]] T cells from elderly individuals had increased [[DUSP4]] transcription (P = 0.002), which inversely correlated with the expression of [[CD4]]0L (r = 0.65, P = 0.002), [[ICOS]] (r = 0.57, P = 0.008), and IL-4 (r = 0.66, P = 0.001). In [[CD4]] KO mice reconstituted with [[DUSP4]] OT-II T cells, [[DUSP4]] had a negative effect on the expansion of antigen-specific B cells (P = 0.003) and the production of ova-specific antibodies (P = 0.03) after immunization. Silencing of [[DUSP4]] in memory [[CD4]] T cells improved [[CD4]]0L (P &lt; 0.001), IL-4 (P = 0.007), and IL-21 (P = 0.04) expression significantly more in the elderly than young adults. Consequently, the ability of [[CD4]] memory T cells to support B-cell differentiation that was impaired in the elderly (P = 0.004) was restored. Our data suggest that increased [[DUSP4]] expression in activated T cells in the elderly in part accounts for defective adaptive immune responses.<br /> |mesh-terms=* Adolescent<br /> * Adult<br /> * Aged<br /> * Aged, 80 and over<br /> * Aging<br /> * Animals<br /> * B-Lymphocytes<br /> * Biomarkers<br /> * CD4-Positive T-Lymphocytes<br /> * Dual-Specificity Phosphatases<br /> * Gene Silencing<br /> * Humans<br /> * Immunity, Humoral<br /> * Immunologic Memory<br /> * Influenza, Human<br /> * Lymphocyte Activation<br /> * Mice<br /> * Mitogen-Activated Protein Kinase Phosphatases<br /> * Protein Tyrosine Phosphatases<br /> * Signal Transduction<br /> * T-Lymphocytes, Helper-Inducer<br /> * Vaccination<br /> * Young Adult<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326453<br /> }}</div>

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