https://transhumanist.ru/index.php?action=history&feed=atom&title=DNMBP 2026-11-09T14:29:45Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=DNMBP&diff=5679&oldid=prev 2021-05-12T13:55:05Z

<p>Новая страница: «Dynamin-binding protein (Scaffold protein Tuba) [ARHGEF36] [KIAA1010] [TUBA] ==Publications== {{medline-entry |title=Dynamin binding protein gene expression and...»</p> <p><b>Новая страница</b></p><div>Dynamin-binding protein (Scaffold protein Tuba) [ARHGEF36] [KIAA1010] [TUBA]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Dynamin binding protein gene expression and memory performance in aged rats.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21232816<br /> |abstract=Previous studies have shown that messenger RNA (mRNA) of the dynamin-binding protein ([[DNMBP]]), a scaffold protein regulating actin cytoskeleton and synaptic vesicle pools, is lower in neuropathologically-confirmed Alzheimer&#039;s brains. Here we investigated whether a deficit in long term memory formation during physiological aging is also associated with lower [[DNMBP]] expression. Hippocampal [[DNMBP]] mRNA was quantified by quantitative real time reverse transcriptase polymerase chain reaction (qRT-PCR) following inhibitory avoidance task in aged (26- to 27-month-old) rats that, according to memory performance, were ranked as good responders (GR) and bad responders (BR), in adult (3-month-old), late-adult (19-month-old), and aged (26-27-month-old) naive animals. We found that [[DNMBP]] mRNA levels were significantly higher in naive adults versus late adult and aged naive rats, in GR versus BR, and in pooled GR and BR versus aged-matched controls. Our data provide the first evidence that hippocampal [[DNMBP]] mRNA expression is reduced during physiological aging, and suggest that the capability to increase the expression of this mRNA may be a requirement for preserving long term memory formation during aging.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Avoidance Learning<br /> * Carrier Proteins<br /> * Cytoskeletal Proteins<br /> * Down-Regulation<br /> * Female<br /> * Gene Expression Regulation<br /> * Hippocampus<br /> * Memory, Long-Term<br /> * Protein Binding<br /> * Rats<br /> * Rats, Wistar<br /> * Real-Time Polymerase Chain Reaction<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2010.11.012<br /> }}</div>

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