https://transhumanist.ru/index.php?action=history&feed=atom&title=DNAJB9 2026-06-06T08:43:38Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=DNAJB9&diff=6396&oldid=prev 2021-05-12T15:28:14Z

<p>Новая страница: «DnaJ homolog subfamily B member 9 precursor (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endotheli...»</p> <p><b>Новая страница</b></p><div>DnaJ homolog subfamily B member 9 precursor (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1) [MDG1] [UNQ743/PRO1471]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[DNAJB9]] Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32264658<br /> |abstract=[i][[DNAJB9]][/i] is known to be a member of the molecular chaperone gene family, whose cellular function has not yet been fully characterized. Here, we investigated the cellular function of [[DNAJB9]] under strong mitogenic signals. We found that [[DNAJB9]] inhibits p53-dependent oncogene-induced senescence (OIS) and induces neoplastic transformation under oncogenic RAS activation in mouse primary fibroblasts. In addition, we observed that [[DNAJB9]] interacts physically with p53 under oncogenic RAS activation and that the p53-interacting region of [[DNAJB9]] is critical for the inhibition of p53-dependent OIS and induction of neoplastic transformation by [[DNAJB9]]. These results suggest that [[DNAJB9]] induces cell transformation under strong mitogenic signals, which is attributable to the inhibition of p53-dependent OIS by physical interactions with p53. This study might contribute to our understanding of the cellular function of [[DNAJB9]] and the molecular basis of cell transformation.<br /> <br /> |keywords=* DNAJB9<br /> * RAS<br /> * p53<br /> * senescence<br /> * transformation<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191047<br /> }}</div>

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