https://transhumanist.ru/index.php?action=history&feed=atom&title=DLGAP2 2026-06-20T19:35:58Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=DLGAP2&diff=4543&oldid=prev 2021-04-29T19:23:07Z

<p>Новая страница: «Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2) [C8orf68] [DAP2] [ERICH1-AS1] ==Publicatio...»</p> <p><b>Новая страница</b></p><div>Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2) [C8orf68] [DAP2] [ERICH1-AS1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer&#039;s Dementia.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32877673<br /> |abstract=Genetic mechanisms underlying age-related cognitive decline and dementia remain poorly understood. Here, we take advantage of the Diversity Outbred mouse population to utilize quantitative trait loci mapping and identify Dlgap2 as a positional candidate responsible for modifying working memory decline. To evaluate the translational relevance of this finding, we utilize longitudinal cognitive measures from human patients, RNA expression from post-mortem brain tissue, data from a genome-wide association study (GWAS) of Alzheimer&#039;s dementia (AD), and GWAS results in African Americans. We find an association between Dlgap2 and AD phenotypes at the variant, gene and protein expression, and methylation levels. Lower cortical [[DLGAP2]] expression is observed in AD and is associated with more plaques and tangles at autopsy and faster cognitive decline. Results will inform future studies aimed at investigating the cross-species role of Dlgap2 in regulating cognitive decline and highlight the benefit of using genetically diverse mice to prioritize novel candidates.<br /> <br /> |keywords=* Alzheimer’s<br /> * Diversity Outbred<br /> * Dlgap2<br /> * GWAS<br /> * aging<br /> * cognition<br /> * genetic diversity<br /> * resilience<br /> * spines<br /> * susceptibility<br /> * translational<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502175<br /> }}</div>

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