https://transhumanist.ru/index.php?action=history&feed=atom&title=DLG1DLG1 - История изменений2026-06-17T16:55:36ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=DLG1&diff=6386&oldid=prevOdysseusBot: Новая страница: «Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) ==Publications== {{medline-entry |title=Altered expression of genes for Kir ion ch...»2021-05-12T15:27:46Z<p>Новая страница: «Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) ==Publications== {{medline-entry |title=Altered expression of genes for Kir ion ch...»</p>
<p><b>Новая страница</b></p><div>Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Altered expression of genes for Kir ion channels in dilated cardiomyopathy.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23889090<br />
|abstract=Dilated cardiomyopathy (DCM) is a multifactorial disease characterized by left ventricular dilation that is associated with systolic dysfunction and increased action potential duration. The Kir2.x K⁺ channels (encoded by KCNJ genes) regulate the inward rectifier current (IK1) contributing to the final repolarization in cardiac muscle. Here, we describe the transitions in the gene expression profiles of 4 KCNJ genes from healthy or dilated cardiomyopathic human hearts. In the healthy adult ventricles, [[KCNJ2]], [[KCNJ12]], and [[KCNJ4]] (Kir2.1-2.3, respectively) genes were expressed at high levels, while expression of the [[KCNJ14]] (Kir2.4) gene was low. In DCM ventricles, the levels of Kir2.1 and Kir2.3 were upregulated, but those of Kir2.2 channels were downregulated. Additionally, the expression of the [[DLG1]] gene coding for the synapse-associated protein 97 (SAP97) anchoring molecule exhibited a 2-fold decline with increasing age in normal hearts, and it was robustly downregulated in young DCM patients. These adaptations could offer a new aspect for the explanation of the generally observed physiological and molecular alterations found in DCM.<br />
|mesh-terms=* Adolescent<br />
* Adult<br />
* Aging<br />
* Blotting, Western<br />
* Cardiomyopathy, Dilated<br />
* Female<br />
* Gene Expression<br />
* Heart Ventricles<br />
* Humans<br />
* Male<br />
* Membrane Potentials<br />
* Middle Aged<br />
* Myocytes, Cardiac<br />
* Patch-Clamp Techniques<br />
* Potassium Channels, Inwardly Rectifying<br />
* Protein Isoforms<br />
* Reverse Transcriptase Polymerase Chain Reaction<br />
* Young Adult<br />
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|full-text-url=https://sci-hub.do/10.1139/cjpp-2012-0413<br />
}}</div>OdysseusBot