https://transhumanist.ru/index.php?action=history&feed=atom&title=DHX57 2026-04-09T23:07:05Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=DHX57&diff=6374&oldid=prev 2021-05-12T15:27:12Z

<p>Новая страница: «ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) ==Publications== {{medline-entry |title=Genetic variants near <a href="/MLST8" title="MLST8">MLST8</a> and <a href="/DHX57" title="DHX57">DHX57</a> affec...»</p> <p><b>Новая страница</b></p><div>ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Genetic variants near [[MLST8]] and [[DHX57]] affect the epigenetic age of the cerebellum.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26830004<br /> |abstract=DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the &#039;epigenetic clock&#039;. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant (P&lt;5.0 × 10(-8)) SNPs in two loci: 2p22.1 (inside gene [[DHX57]]) and 16p13.3 near gene [[MLST8]] (a subunit of mTOR complex 1 and 2). We find that the SNP in 16p13.3 has a cis-acting effect on the expression levels of [[MLST8]] (P=6.9 × 10(-18)) in most brain regions. In cerebellar samples, the SNP in 2p22.1 has a cis-effect on [[DHX57]] (P=4.4 × 10(-5)). Gene sets found by our GWAS analysis of cerebellar age acceleration exhibit significant overlap with those of Alzheimer&#039;s disease (P=4.4 × 10(-15)), age-related macular degeneration (P=6.4 × 10(-6)), and Parkinson&#039;s disease (P=2.6 × 10(-4)). Overall, our results demonstrate the utility of a new paradigm for understanding aging and age-related diseases: it will be fruitful to use epigenetic tissue age as endophenotype in GWAS. <br /> |mesh-terms=* Adaptor Proteins, Signal Transducing<br /> * Aging<br /> * Cell Line<br /> * Cerebellum<br /> * Epigenesis, Genetic<br /> * Gene Expression Regulation<br /> * Genetic Variation<br /> * Genome-Wide Association Study<br /> * Humans<br /> * Linkage Disequilibrium<br /> * mTOR Associated Protein, LST8 Homolog<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740877<br /> }}</div>

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