https://transhumanist.ru/index.php?action=history&feed=atom&title=CST1 2026-06-11T22:15:10Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CST1&diff=5291&oldid=prev 2021-05-12T13:37:51Z

<p>Новая страница: «Cystatin-SN precursor (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1) ==Publications== {{medline-entry |title=Novel expression of <a href="/CST1" title="CST1">CST1</a> as candidate sen...»</p> <p><b>Новая страница</b></p><div>Cystatin-SN precursor (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Novel expression of [[CST1]] as candidate senescence marker.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21636832<br /> |abstract=Senescent cells exhibit altered expression of numerous genes. Identifying the significance of the changes in gene expression may help advance our understanding of the senescence biology. Here, we report on the consistent and strong upregulation of [[CST1]] expression during cellular senescence, independent of the initial trigger. [[CST1]] expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts and various human tumor cell lines. Immunoblotting and immunofluorescence cytochemical studies further suggest that [[CST1]] accumulates intracellularly, within vesicular structures. We discuss these results in light of the known function of [[CST1]] as a potent inhibitor of lysosomal cysteine proteases.<br /> |mesh-terms=* Aging<br /> * Biomarkers<br /> * Blotting, Western<br /> * Cells, Cultured<br /> * Cellular Senescence<br /> * Electrophoresis, Polyacrylamide Gel<br /> * Fibroblasts<br /> * Gene Expression<br /> * Humans<br /> * Immunohistochemistry<br /> * RNA<br /> * Salivary Cystatins<br /> <br /> |full-text-url=https://sci-hub.do/10.1093/gerona/glr033<br /> }}</div>

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