https://transhumanist.ru/index.php?action=history&feed=atom&title=CSNK1G2 2026-08-14T05:54:45Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CSNK1G2&diff=3917&oldid=prev 2021-04-29T18:51:28Z

<p>Новая страница: «Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2) [CK1G2] ==Publications== {{medline-entry |title=Casein kinase 1G2 suppresses necroptosis-promoted te...»</p> <p><b>Новая страница</b></p><div>Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2) [CK1G2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33206046<br /> |abstract=Casein kinases are a large family of intracellular serine/threonine kinases that control a variety of cellular signaling functions. Here we report that a member of casein kinase 1 family, casein kinase 1G2, [[CSNK1G2]], binds and inhibits the activation of receptor-interacting kinase 3, [[RIPK3]], thereby attenuating [[RIPK3]]-mediated necroptosis. The binding of [[CSNK1G2]] to [[RIPK3]] is triggered by auto-phosphorylation at serine 211/threonine 215 sites in its C-terminal domain. [[CSNK1G2]]-knockout mice showed significantly enhanced necroptosis response and premature aging of their testis, a phenotype that was rescued by either double knockout of the [i]Ripk3[/i] gene or feeding the animal with a [[RIPK1]] kinase inhibitor-containing diet. Moreover, [[CSNK1G2]] is also co-expressed with [[RIPK3]] in human testis, and the necroptosis activation marker phospho-[[MLKL]] was observed in the testis of old (&gt;80) but not young men, indicating that the testis-aging program carried out by the [[RIPK3]]-mediated and [[CSNK1G2]]-attenuated necroptosis is evolutionarily conserved between mice and men.<br /> <br /> |keywords=* aging<br /> * cell biology<br /> * mouse<br /> * necroptosis<br /> * protein kinase<br /> * reproductivity<br /> * testis<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673785<br /> }}</div>

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