https://transhumanist.ru/index.php?action=history&feed=atom&title=COX7A1 2026-07-04T23:41:39Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=COX7A1&diff=5639&oldid=prev 2021-05-12T13:53:19Z

<p>Новая страница: «Cytochrome c oxidase subunit 7A1, mitochondrial precursor (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase su...»</p> <p><b>Новая страница</b></p><div>Cytochrome c oxidase subunit 7A1, mitochondrial precursor (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M) [COX7AH]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Age influences DNA methylation and gene expression of [[COX7A1]] in human skeletal muscle.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18488190<br /> |abstract=Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-genetic factors influence a component of the respiratory chain, [[COX7A1]], previously shown to be downregulated in skeletal muscle from patients with type 2 diabetes. The specific aims were to: (1) evaluate the impact of genetic (single nucleotide polymorphisms [SNPs]), epigenetic (DNA methylation) and non-genetic (age) factors on the expression of [[COX7A1]] in human skeletal muscle; and (2) investigate whether common variants in the [[COX7A1]] gene are associated with increased risk of type 2 diabetes. [[COX7A1]] mRNA expression was analysed in muscle biopsies from young (n = 110) and elderly (n = 86) non-diabetic twins and related to measures of in vivo metabolism. Genetic variants (three SNPs) from the [[COX7A1]] locus were genotyped in the twins and in two independent type 2 diabetes case-control cohorts (n = 1466 and 6380, respectively). DNA methylation of the [[COX7A1]] promoter was analysed in a subset of twins (ten young, ten elderly) using bisulphite sequencing. While DNA methylation of the [[COX7A1]] promoter was increased in muscle from elderly compared with young twins (19.9 /- 8.3% vs 1.8 /- 2.7%; p = 0.035), the opposite was found for [[COX7A1]] mRNA expression (elderly 1.00 /- 0.05 vs young 1.68 /- 0.06; p = 0.0005). The heritability of [[COX7A1]] expression was estimated to be 50% in young and 72% in elderly twins. One of the polymorphisms investigated, rs753420, influenced basal [[COX7A1]] expression in muscle of young (p = 0.0001) but not of elderly twins. The transcript level of [[COX7A1]] was associated with increased in vivo glucose uptake and VO(2max) (p = 0.009 and p = 0.001, respectively). We did not observe any genetic association between [[COX7A1]] polymorphisms and type 2 diabetes after correcting for multiple testing. Our results provide further evidence for age as a factor influencing DNA methylation and expression of OXPHOS genes, and thereby in vivo metabolism.<br /> |mesh-terms=* Adult<br /> * Aged<br /> * Aging<br /> * Biopsy<br /> * DNA Methylation<br /> * Diabetes Mellitus, Type 2<br /> * Electron Transport Complex IV<br /> * Epigenesis, Genetic<br /> * Female<br /> * Gene Expression Regulation<br /> * Genetic Predisposition to Disease<br /> * Humans<br /> * Insulin Resistance<br /> * Male<br /> * Middle Aged<br /> * Muscle, Skeletal<br /> * Oxidative Phosphorylation<br /> * Polymorphism, Single Nucleotide<br /> * Promoter Regions, Genetic<br /> * RNA, Messenger<br /> * Risk Factors<br /> <br /> |full-text-url=https://sci-hub.do/10.1007/s00125-008-1018-8<br /> }}</div>

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