https://transhumanist.ru/index.php?action=history&feed=atom&title=COL5A1COL5A1 - История изменений2026-09-05T23:15:00ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=COL5A1&diff=5689&oldid=prevOdysseusBot: Новая страница: «Collagen alpha-1(V) chain precursor ==Publications== {{medline-entry |title=Range of motion measurements diverge with increasing age for COL5A1 genotypes. |...»2021-05-12T13:55:30Z<p>Новая страница: «Collagen alpha-1(V) chain precursor ==Publications== {{medline-entry |title=Range of motion measurements diverge with increasing age for <a href="/COL5A1" title="COL5A1">COL5A1</a> genotypes. |...»</p>
<p><b>Новая страница</b></p><div>Collagen alpha-1(V) chain precursor<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Range of motion measurements diverge with increasing age for [[COL5A1]] genotypes.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21362053<br />
|abstract=Increased and decreased joint range of motion (ROM) are modifiable risk factors for musculoskeletal soft-tissue injuries. Certain heritable disorders of connective tissue, which have a unifying symptom of joint hypermobility, are caused by mutations within the [[COL5A1]] gene. Furthermore, the [[COL5A1]] BstUI restriction fragment length polymorphism (RFLP) sequence variant is associated with ROM measurements in a mixed injured/uninjured cohort. The association between [[COL5A1]] BstUI RFLP and sit and reach (SR) ROM in an apparently healthy and physically active cohort was investigated. The SR test was performed on 325 white subjects (204 males). Subjects were also genotyped for the BstUI RFLP (C/T) within the 3'-untranslated region of the [[COL5A1]] gene. The [[COL5A1]] BstUI RFLP genotype was associated with SR ROM in older (≥35 years) subjects (TT: 225 ± 96 mm, TC: 245 ± 100 mm, CC: 32 ± 108 mm, N=96, P=0.017). Age and [[COL5A1]] BstUI genotype interacted significantly for SR ROM. Sex and [[COL5A1]] genotype accounted for 22.8% of the variance in SR ROM in the older group. The [[COL5A1]] BstUI RFLP is associated with SR ROM, particularly with increasing age and is an important contributing factor to ROM variation, particularly in older, apparently healthy and physically active individuals.<br />
|mesh-terms=* Adolescent<br />
* Adult<br />
* Aging<br />
* Cohort Studies<br />
* Collagen Type V<br />
* Female<br />
* Genotype<br />
* Humans<br />
* Male<br />
* Middle Aged<br />
* Muscle, Skeletal<br />
* Range of Motion, Articular<br />
* Young Adult<br />
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|full-text-url=https://sci-hub.do/10.1111/j.1600-0838.2010.01271.x<br />
}}</div>OdysseusBot