https://transhumanist.ru/index.php?action=history&feed=atom&title=COL4A2COL4A2 - История изменений2026-06-14T05:09:46ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=COL4A2&diff=5726&oldid=prevOdysseusBot: Новая страница: «Collagen alpha-2(IV) chain precursor [Contains: Canstatin] ==Publications== {{medline-entry |title=Tissue- and developmental stage-specific activation of alpha...»2021-05-12T13:57:02Z<p>Новая страница: «Collagen alpha-2(IV) chain precursor [Contains: Canstatin] ==Publications== {{medline-entry |title=Tissue- and developmental stage-specific activation of alpha...»</p>
<p><b>Новая страница</b></p><div>Collagen alpha-2(IV) chain precursor [Contains: Canstatin]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Tissue- and developmental stage-specific activation of alpha 5 and alpha 6(IV) collagen expression in the upper gastrointestinal tract of transgenic mice.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/14592452<br />
|abstract=Little is known about mechanisms regulating gene expression for the alpha chains of basement membrane type IV collagen, arranged head-to-head in transcription units [[COL4A1]]-[[COL4A2]], [[COL4A3]]-[[COL4A4]], and [[COL4A5]]-[[COL4A6]], and implicated broadly in genetic diseases. To investigate these mechanisms, we generated transgenic mouse lines bearing 5'-flanking sequences of [[COL4A5]] and [[COL4A6]], cloned upstream of a lacZ reporter gene. A 3.8-kb fragment upstream of [[COL4A6]] directs reporter gene expression in the esophagus, stomach, and duodenum, whereas a 13.8-kb fragment directs expression in the esophagus only. A 10.6-kb fragment upstream of [[COL4A5]] directs expression in the esophagus. Coupled with evidence of long-range conservation between human and mouse non-coding sequences, described herein, our findings provide the first indication that highly specialized patterns characteristic of [[COL4A5]]-[[COL4A6]] expression in vivo arise from effects of distributed cis-acting regulatory elements on a bidirectional proximal promoter, itself transcriptionally competent.<br />
|mesh-terms=* Aging<br />
* Amino Acid Sequence<br />
* Animals<br />
* Collagen Type IV<br />
* Gene Expression Regulation<br />
* Genes, Regulator<br />
* Humans<br />
* Mice<br />
* Mice, Transgenic<br />
* Molecular Sequence Data<br />
* Organ Specificity<br />
* Protein Subunits<br />
* Sequence Homology<br />
* Species Specificity<br />
* Tissue Distribution<br />
* Transcriptional Activation<br />
* Upper Gastrointestinal Tract<br />
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|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2003.09.233<br />
}}</div>OdysseusBot