https://transhumanist.ru/index.php?action=history&feed=atom&title=CLEC3B 2026-06-14T23:33:25Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CLEC3B&diff=6223&oldid=prev 2021-05-12T15:17:50Z

<p>Новая страница: «Tetranectin precursor (TN) (C-type lectin domain family 3 member B) (Plasminogen kringle 4-binding protein) [TNA] ==Publications== {{medline-entry |title=CLEC...»</p> <p><b>Новая страница</b></p><div>Tetranectin precursor (TN) (C-type lectin domain family 3 member B) (Plasminogen kringle 4-binding protein) [TNA]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[CLEC3B]] p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570938<br /> |abstract=A number of efforts are underway to better understand the role of genetic variation in successful aging and longevity. However, to date, only two genes have been consistently associated with longevity in humans: [[APOE]] and [[FOXO3]], with the [[APOE]] ɛ2 allele also protective against dementia. Recently, using an exome-wide SNP array approach, a missense variant [[CLEC3B]] c.316G&gt;A (rs13963 p.S106G) was reported to associate with longevity in two independent cohorts of Japanese and Chinese participants. Interestingly, [[CLEC3B]] p.S106G is more frequent in Caucasian populations. Herein, we examined the frequency of [[CLEC3B]] p.S106G in a Caucasian series of 1,483 neurologically healthy individuals with a specific subset &gt;80 years of age. Although our findings do not support an association between [[CLEC3B]] p.S106G and aging without neurological disease (p = .89), we confirmed the association between the [[APOE]] ε2 allele and better survival without neurological disease (p = .001). Further assessment of healthy aged cohorts that retain intact neurological function will be critical to understand the etiology of neurodegenerative disease and the role of age at risk.<br /> <br /> |keywords=* <br /> APOE<br /> <br /> * <br /> CLEC3B<br /> <br /> * Aging<br /> * Human genetics<br /> * Human health<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494029<br /> }}<br /> {{medline-entry<br /> |title=Exome-wide Association Study Identifies [[CLEC3B]] Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27154906<br /> |abstract=Life span is a complex trait regulated by multiple genetic and environmental factors; however, the genetic determinants of extreme longevity have been largely unknown. To identify the functional coding variants associated with extreme longevity, we performed an exome-wide association study (EWAS) on a Japanese population by using an Illumina HumanExome Beadchip and a focused replication study on a Chinese population. The EWAS on two independent Japanese cohorts consisting of 530 nonagenarians/centenarians demonstrated that the G allele of [[CLEC3B]] missense variant p.S106G was associated with extreme longevity at the exome-wide level of significance (p = 2.33×10-7, odds ratio [OR] = 1.50). The [[CLEC3B]] gene encodes tetranectin, a protein implicated in the mineralization process in osteogenesis as well as in the prognosis and metastasis of cancer. The replication study consisting of 448 Chinese nonagenarians/centenarians showed that the G allele of [[CLEC3B]] p.S106G was also associated with extreme longevity (p = .027, OR = 1.51), and the p value of this variant reached 1.87×10-8 in the meta-analysis of Japanese and Chinese populations. In conclusion, the present study identified the [[CLEC3B]] p.S106G as a novel longevity-associated variant, raising the novel hypothesis that tetranectin, encoded by [[CLEC3B]], plays a role in human longevity and aging.<br /> |mesh-terms=* Adult<br /> * Aged<br /> * Aged, 80 and over<br /> * Asian Continental Ancestry Group<br /> * Exome<br /> * Female<br /> * Genetic Variation<br /> * Genome-Wide Association Study<br /> * Humans<br /> * Lectins, C-Type<br /> * Longevity<br /> * Male<br /> * Middle Aged<br /> |keywords=* Centenarian<br /> * Human aging<br /> * Human genetics<br /> * Longevity<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861862<br /> }}</div>

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