https://transhumanist.ru/index.php?action=history&feed=atom&title=CINP 2026-06-22T22:15:40Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CINP&diff=6218&oldid=prev 2021-05-12T15:17:33Z

<p>Новая страница: «Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein) ==Publications== {{medline-entry |title=Neuropathology-driven Whole-genome Sequencing S...»</p> <p><b>Новая страница</b></p><div>Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Neuropathology-driven Whole-genome Sequencing Study Points to Novel Candidate Genes for Healthy Brain Aging.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30681437<br /> |abstract=Understanding the healthy brain aging process is key to uncover the mechanisms that lead to pathologic age-related neurodegeneration, including progression to Alzheimer disease (AD). We aimed to address the issue of pathologic heterogeneity that often underlies a clinical AD diagnosis. We performed a deep whole-genome sequencing study aiming to identify variants that are associated specifically with healthy brain aging. We examined samples from the community-based longitudinal Vienna Transdanubian Aging study comparing neuropathologically &quot;healthy&quot; aging in individuals above 80 years of age with pure AD patients of the same age. Focusing on potentially functional variants, we discovered a single variant (rs10149146) that lies on the autophagy-associated [[TECPR2]] gene and was carried by 53.6% of the &quot;healthy&quot; brain elderly individuals (15/28). An additional nonsynonymous variant on the [[CINP]] gene (encoding a cell cycle checkpoint protein) was also found in 46% of healthy controls. Both variants are absent from all AD cases. [[TECPR2]] and [[CINP]] appear to be &quot;partner&quot; genes in terms of regulation and their associated transcription factors have been previously implicated in AD and neurodegeneration. Our study underlines the strength of neuropathology-driven definitions in genetic association studies and points to a potentially neuroprotective effect of key molecules of autophagy and cell cycle control.<br /> |mesh-terms=* Aged, 80 and over<br /> * Aging<br /> * Alzheimer Disease<br /> * Austria<br /> * Brain<br /> * Carrier Proteins<br /> * Female<br /> * Humans<br /> * Longitudinal Studies<br /> * Male<br /> * Nerve Tissue Proteins<br /> * Neuropathology<br /> * Whole Genome Sequencing<br /> <br /> |full-text-url=https://sci-hub.do/10.1097/WAD.0000000000000294<br /> }}</div>

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