https://transhumanist.ru/index.php?action=history&feed=atom&title=CGN 2026-06-08T11:26:45Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CGN&diff=5124&oldid=prev 2021-05-12T13:30:15Z

<p>Новая страница: «Cingulin [KIAA1319] ==Publications== {{medline-entry |title=Effect of N-methyl-D-aspartate receptor blockade on caspase activation and neuronal death in the dev...»</p> <p><b>Новая страница</b></p><div>Cingulin [KIAA1319]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Effect of N-methyl-D-aspartate receptor blockade on caspase activation and neuronal death in the developing rat cerebellum.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16781062<br /> |abstract=In vitro studies have demonstrated that N-methyl-D-aspartate (NMDA) receptor activation rescue cerebellar granule neurons ([[CGN]]) from apoptotic death. It has been suggested that this effect mimics the transient glutamate receptors activation by mossy fibers during cerebellar development. We reported previously that [[CGN]] from postnatal days 2-4 (P2-P4) rats increased cell survival in response to NMDA treatment. In this study, we evaluated the effect of dizocilpine (MK-801) administrated for three consecutive days on the apoptotic death of [[CGN]] during development. MK-801 treatment decreased the large number of [[CGN]] condensed nuclei found at P8, but this drug increased the proportion of condensed nuclei at P16. We also found a high activity of caspases during the first postnatal week that decreased during development. MK-801 treatment did not modify the activity of caspase-8 at any age, but decreased caspase-9 activity at P8 and increased the activity of caspase-1 (76%) at P8, caspase-3 (160%) at P16 and caspase-9 (50%) at P12. These results suggest that NMDA receptor stimulation regulates the activity of caspases in a differential way and plays an important role in the in vivo [[CGN]] death during postnatal development.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Caspases<br /> * Cerebellum<br /> * Dizocilpine Maleate<br /> * Enzyme Activation<br /> * Excitatory Amino Acid Antagonists<br /> * Models, Animal<br /> * Rats<br /> * Rats, Wistar<br /> * Receptors, N-Methyl-D-Aspartate<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.neulet.2006.05.039<br /> }}</div>

OdysseusBot