https://transhumanist.ru/index.php?action=history&feed=atom&title=CGAS 2026-10-22T19:56:10Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CGAS&diff=5465&oldid=prev 2021-05-12T13:45:11Z

<p>Новая страница: «Cyclic GMP-AMP synthase (EC 2.7.7.86) (cGAMP synthase) (cGAS) (h-cGAS) (2&#039;3&#039;-cGAMP synthase) (Mab-21 domain-containing protein 1) [C6orf150] [MB21D1] ==Publicati...»</p> <p><b>Новая страница</b></p><div>Cyclic GMP-AMP synthase (EC 2.7.7.86) (cGAMP synthase) (cGAS) (h-cGAS) (2&#039;3&#039;-cGAMP synthase) (Mab-21 domain-containing protein 1) [C6orf150] [MB21D1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Controlled study of switching from attention-deficit/hyperactivity disorder to a prepubertal and early adolescent bipolar I disorder phenotype during 6-year prospective follow-up: rate, risk, and predictors.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17064428<br /> |abstract=Rate, risk, and predictors of switching from attention-deficit/hyperactivity disorder (ADHD) to a prepubertal and early adolescent bipolar I disorder phenotype (PEA-BP-I) were examined in a blindly rated, controlled, prospective 6-year follow-up that included assessments at 2-year intervals. Subjects were outpatients obtained by consecutive new case ascertainment. There were 81 subjects who were 9.7 /- 2.0 years. Subjects had DSM-IV ADHD (hyperactive or combined subtypes); a Children&#039;s Global Assessment Scale ([[CGAS]]) score of &lt; or =60, consistent with moderate-severe impairment; and no BP or major depressive disorder (MDD) diagnoses. PEA-BP-I was defined as DSM-IV BP I (manic or mixed phase), with cardinal symptoms (elation and/or grandiosity), to avoid diagnosing mania by symptoms that overlapped with those of ADHD, and by a [[CGAS]] score of &lt; or =60. Morbid risk of switching to PEA-BP-I was 28.5%. Significant predictors of switching in a multivariate Cox model were more severe baseline [[CGAS]], paternal recurrent MDD, and less stimulant use. BP I in first-degree relatives, antidepressants, psychosocial measures, and life events were not predictive.<br /> |mesh-terms=* Adolescent<br /> * Aging<br /> * Antidepressive Agents<br /> * Attention Deficit Disorder with Hyperactivity<br /> * Bipolar Disorder<br /> * Central Nervous System Stimulants<br /> * Child<br /> * Female<br /> * Follow-Up Studies<br /> * Humans<br /> * Male<br /> * Nuclear Family<br /> * Outpatients<br /> * Phenotype<br /> * Puberty<br /> * Social Behavior<br /> <br /> |full-text-url=https://sci-hub.do/10.1017/S0954579406060512<br /> }}</div>

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