https://transhumanist.ru/index.php?action=history&feed=atom&title=CDK16 2026-04-09T13:52:16Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CDK16&diff=4016&oldid=prev 2021-04-29T18:56:30Z

<p>Новая страница: «Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) [PCTAIRE1...»</p> <p><b>Новая страница</b></p><div>Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) [PCTAIRE1] [PCTK1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23707792<br /> |abstract=Microarray gene expression data were used to analyze the expression pattern of cyclin, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitor (CDKIs) genes from human pancreatic islets with and without type 2 diabetes (T2D). Of the cyclin genes, [[CCNI]] was the most expressed. Data obtained from microarray and qRT-PCR showed higher expression of [[CCND1]] in diabetic islets. Among the CDKs, [[CDK4]], [[CDK8]] and [[CDK9]] were highly expressed, while [[CDK1]] was expressed at low level. High expression of [[[[CDK1]]8]] was observed in diabetic islets. Of the CDKIs, [[CDKN1A]] expression was higher in diabetic islets in both microarray and qRT-PCR. Expression of [[CDKN1A]], [[[[CDKN2A]]]], [[CCNI]]2, [[CDK3]] and [[CDK1]]6 was correlated with age. Finally, eight SNPs in these genes were associated with T2D in the DIAGRAM database. Our data provide a comprehensive expression pattern of cell cycle genes in human islets. More human studies are required to confirm and reproduce animal studies. <br /> |mesh-terms=* Aged<br /> * Aging<br /> * Case-Control Studies<br /> * Cells, Cultured<br /> * Cyclin-Dependent Kinase Inhibitor Proteins<br /> * Cyclin-Dependent Kinases<br /> * Cyclins<br /> * Diabetes Mellitus, Type 2<br /> * Female<br /> * Gene Expression Profiling<br /> * Genes, cdc<br /> * Genetic Association Studies<br /> * Genetic Predisposition to Disease<br /> * Humans<br /> * Insulin<br /> * Insulin Secretion<br /> * Islets of Langerhans<br /> * Male<br /> * Middle Aged<br /> * Oligonucleotide Array Sequence Analysis<br /> * Polymorphism, Single Nucleotide<br /> * Transcriptome<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.mce.2013.05.003<br /> }}</div>

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