https://transhumanist.ru/index.php?action=history&feed=atom&title=CDH2 2026-06-22T19:07:57Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CDH2&diff=6156&oldid=prev 2021-05-12T15:14:31Z

<p>Новая страница: «Cadherin-2 precursor (CDw325) (Neural cadherin) (N-cadherin) (CD325 antigen) [CDHN] [NCAD] ==Publications== {{medline-entry |title=CellBIC: bimodality-based top...»</p> <p><b>Новая страница</b></p><div>Cadherin-2 precursor (CDw325) (Neural cadherin) (N-cadherin) (CD325 antigen) [CDHN] [NCAD]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=CellBIC: bimodality-based top-down clustering of single-cell RNA sequencing data reveals hierarchical structure of the cell type.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30102368<br /> |abstract=Single-cell RNA sequencing (scRNA-seq) is a powerful tool to study heterogeneity and dynamic changes in cell populations. Clustering scRNA-seq is essential in identifying new cell types and studying their characteristics. We develop CellBIC (single Cell BImodal Clustering) to cluster scRNA-seq data based on modality in the gene expression distribution. Compared with classical bottom-up approaches that rely on a distance metric, CellBIC performs hierarchical clustering in a top-down manner. CellBIC outperformed the bottom-up hierarchical clustering approach and other recently developed clustering algorithms while maintaining the hierarchical structure of cells. Importantly, CellBIC identifies type 2 diabetes and age specific β cell signatures characterized by [[SIX3]] and [[CDH2]], respectively.<br /> |mesh-terms=* Aging<br /> * Algorithms<br /> * Antigens, CD<br /> * Cadherins<br /> * Cluster Analysis<br /> * Computational Biology<br /> * Diabetes Mellitus, Type 2<br /> * Gene Expression Profiling<br /> * Genetic Markers<br /> * Humans<br /> * Islets of Langerhans<br /> * Pancreas<br /> * Sequence Analysis, RNA<br /> * Single-Cell Analysis<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265269<br /> }}</div>

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