https://transhumanist.ru/index.php?action=history&feed=atom&title=CDC73 2026-09-23T18:17:46Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CDC73&diff=6152&oldid=prev 2021-05-12T15:14:20Z

<p>Новая страница: «Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) [C1orf28] [HRPT2] ==Publications== {{medline-entry |title=Down-regulation...»</p> <p><b>Новая страница</b></p><div>Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) [C1orf28] [HRPT2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Down-regulation of cancer-associated gene [[CDC73]] contributes to cellular senescence.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29621547<br /> |abstract=Dysregulated gene expression is another important contributor in explaining cancer-related phenotypes in addition to mutations. Cellular senescence is a mechanism for the prevention of cancer and thus it is important to understand the regulation of gene expression in senescence due to its potential in anti-cancer therapy. Here, we found that [[CDC73]], which encodes the cell division cycle 73 and acts as a tumor suppressor, was unexpectedly up-regulated in several cancer types but down-regulated in a variety of senescent cells. Importantly, depletion of [[CDC73]] could induce senescence-associated phenotypes in both normal and cancer cells, with an increase in p21 expression. In terms of molecular mechanism, alternative polyadenylation (APA)-mediated 3&#039; untranslated region (3&#039; UTR) lengthening explained, at least in part, the decreased [[CDC73]] expression in senescent cells because longer 3&#039; UTR had a higher rate of RNA degradation compared to the shorter one. Our work discovered that post-transcriptional down-regulation of [[CDC73]] contributed to cellular senescence.<br /> |mesh-terms=* 3&#039; Untranslated Regions<br /> * Base Sequence<br /> * Cell Line<br /> * Cellular Senescence<br /> * Cyclin-Dependent Kinase Inhibitor p21<br /> * Down-Regulation<br /> * Gene Expression Regulation, Neoplastic<br /> * Gene Knockdown Techniques<br /> * Humans<br /> * Neoplasms<br /> * Tumor Suppressor Proteins<br /> * Up-Regulation<br /> |keywords=* 3′ UTR<br /> * CDC73<br /> * Cancer<br /> * Cellular senescence<br /> * Gene expression<br /> |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2018.03.228<br /> }}</div>

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