https://transhumanist.ru/index.php?action=history&feed=atom&title=CD226 2026-06-23T18:22:54Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CD226&diff=6118&oldid=prev 2021-05-12T15:12:38Z

<p>Новая страница: «CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1) [DNAM1] ==Publications== {{medline-entry |title=T-cell Immunoglobulin and ITIM Domain Contributes t...»</p> <p><b>Новая страница</b></p><div>CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1) [DNAM1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=T-cell Immunoglobulin and ITIM Domain Contributes to CD8 T-cell Immunosenescence.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29349889<br /> |abstract=Aging is associated with immune dysfunction, especially T-cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between T-cell exhaustion and T-cell senescence. In this study, we showed that T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain ([[TIGIT]]), a novel co-inhibitory receptor, was upregulated in CD8 T cells of elderly adults. Aged [[TIGIT]] CD8 T cells expressed high levels of other inhibitory receptors including PD-1 and exhibited features of exhaustion such as downregulation of the key costimulatory receptor [[CD28]], representative intrinsic transcriptional regulation, low production of cytokines, and high susceptibility to apoptosis. Importantly, their functional defects associated with aging were reversed by [[TIGIT]] knockdown. [[CD226]] downregulation on aged [[TIGIT]] CD8 T cells is likely involved in [[TIGIT]]-mediated negative immune suppression. Collectively, our findings indicated that [[TIGIT]] acts as a critical immune regulator during aging, providing a strong rationale for targeting [[TIGIT]] to improve dysfunction related to immune system aging.<br /> |mesh-terms=* Adult<br /> * Aged<br /> * Animals<br /> * CD8-Positive T-Lymphocytes<br /> * Humans<br /> * Immunoglobulins<br /> * Immunosenescence<br /> * Mice<br /> * Middle Aged<br /> * Receptors, Immunologic<br /> |keywords=* <br /> TIGIT<br /> <br /> * CD8 T cells<br /> * T-cell immunosenescence<br /> * aging<br /> * co-inhibitory receptors<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847879<br /> }}</div>

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