https://transhumanist.ru/index.php?action=history&feed=atom&title=CCNA1CCNA1 - История изменений2026-04-12T19:43:00ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=CCNA1&diff=6093&oldid=prevOdysseusBot: Новая страница: «Cyclin-A1 ==Publications== {{medline-entry |title=Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. |pubme...»2021-05-12T15:11:24Z<p>Новая страница: «Cyclin-A1 ==Publications== {{medline-entry |title=Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. |pubme...»</p>
<p><b>Новая страница</b></p><div>Cyclin-A1<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28920919<br />
|abstract=Inadequate pancreatic β cell function underlies type 1 and type 2 diabetes mellitus. Strategies to expand functional cells have focused on discovering and controlling mechanisms that limit the proliferation of human β cells. Here, we developed an engraftment strategy to examine age-associated human islet cell replication competence and reveal mechanisms underlying age-dependent decline of β cell proliferation in human islets. We found that exendin-4 (Ex-4), an agonist of the glucagon-like peptide 1 receptor (GLP-1R), stimulates human β cell proliferation in juvenile but not adult islets. This age-dependent responsiveness does not reflect loss of GLP-1R signaling in adult islets, since Ex-4 treatment stimulated insulin secretion by both juvenile and adult human β cells. We show that the mitogenic effect of Ex-4 requires calcineurin/nuclear factor of activated T cells (NFAT) signaling. In juvenile islets, Ex-4 induced expression of calcineurin/NFAT signaling components as well as target genes for proliferation-promoting factors, including [[NFATC1]], [[FOXM1]], and [[CCNA1]]. By contrast, expression of these factors in adult islet β cells was not affected by Ex-4 exposure. These studies reveal age-dependent signaling mechanisms regulating human β cell proliferation, and identify elements that could be adapted for therapeutic expansion of human β cells.<br />
|mesh-terms=* Adult<br />
* Aging<br />
* Animals<br />
* Calcineurin<br />
* Cyclin A1<br />
* Exenatide<br />
* Female<br />
* Forkhead Box Protein M1<br />
* Glucagon-Like Peptide 1<br />
* Glucagon-Like Peptide-1 Receptor<br />
* Humans<br />
* Insulin<br />
* Insulin Secretion<br />
* Insulin-Secreting Cells<br />
* Male<br />
* Mice, Inbred NOD<br />
* Middle Aged<br />
* NFATC Transcription Factors<br />
* Peptides<br />
* Signal Transduction<br />
* Venoms<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617654<br />
}}</div>OdysseusBot