https://transhumanist.ru/index.php?action=history&feed=atom&title=CBX6CBX6 - История изменений2026-04-13T03:27:20ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=CBX6&diff=6063&oldid=prevOdysseusBot: Новая страница: «Chromobox protein homolog 6 ==Publications== {{medline-entry |title=Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitme...»2021-05-12T15:09:19Z<p>Новая страница: «Chromobox protein homolog 6 ==Publications== {{medline-entry |title=Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitme...»</p>
<p><b>Новая страница</b></p><div>Chromobox protein homolog 6<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32979540<br />
|abstract=Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes that support the formation of inaccessible heterochromatin and suppress expression of cell and tissue-type specific biomarkers during development. Maintenance and formation of heterochromatin critically depends on epigenetic regulators that recognize histone 3 lysine trimethylation at residues K9 and K27 (respectively, H3K9me3 and H3K27me3), which represent transcriptionally suppressive epigenetic marks. Three chromobox proteins (i.e., [[CBX1]], [[CBX3]] or CBX5) associated with the heterochromatin protein 1 (HP1) complex are methyl readers that interpret H3K9me3 marks which are mediated by H3K9 methyltransferases (i.e., [[SUV39H1]] or SUV39H2). Other chromobox proteins (i.e., [[CBX2]], [[CBX4]], [[CBX6]], [[CBX7]] and CBX8) recognize H3K27me3, which is deposited by Polycomb Repressive Complex 2 (PRC2; a complex containing [[SUZ12]], [[EED]], RBAP46/48 and the methyl transferases [[EZH1]] or EZH2). This second set of CBX proteins resides in [[PRC1]], which has many subunits including other polycomb group factors (PCGF1, [[PCGF2]], [[PCGF3]], PCGF4, [[PCGF5]], PCGF6), human polyhomeotic homologs (HPH1, HPH2, HPH3) and E3-ubiquitin ligases (RING1 or RING2). The latter enzymes catalyze the subsequent mono-ubiquitination of lysine 119 in H2A (H2AK119ub). We discuss biological, cellular and molecular functions of CBX proteins and their physiological and pathological activities in non-skeletal cells and tissues in anticipation of new discoveries on novel roles for CBX proteins in bone formation and skeletal development.<br />
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|keywords=* Aging<br />
* Bone<br />
* CBX1<br />
* CBX2<br />
* CBX3<br />
* CBX4<br />
* CBX5<br />
* CBX6<br />
* CBX7<br />
* CBX8<br />
* Cancer<br />
* Chromatin<br />
* Development<br />
* Epigenetics<br />
* H3K27me3<br />
* H3K9me3<br />
* Lineage-commitment<br />
* Osteoblast<br />
* Senescence<br />
* Stem cell<br />
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115659<br />
}}</div>OdysseusBot