https://transhumanist.ru/index.php?action=history&feed=atom&title=CASR 2026-05-12T02:24:26Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CASR&diff=5311&oldid=prev 2021-05-12T13:38:39Z

<p>Новая страница: «Extracellular calcium-sensing receptor precursor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) [GPRC2A] [PCAR1] ==Publications== {{...»</p> <p><b>Новая страница</b></p><div>Extracellular calcium-sensing receptor precursor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) [GPRC2A] [PCAR1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11248745<br /> |abstract=Bone mineral density (BMD) in adolescence is under strong genetic control. The calcium sensing receptor ([[CASR]]) is involved in the regulation of calcium homeostasis and bone resorption. The A986S polymorphism of the [[CASR]] has recently been associated with serum calcium levels, in one hitherto unconfirmed report. We investigated whether this polymorphism was related to BMD, circulating calcium and parathyroid hormone ([[PTH]]) concentrations in girls. BMD, plasma calcium and serum [[PTH]] were measured in adolescent girls and compared with regard to [[CASR]] genotype. In 97 healthy Caucasian girls (mean age 16.9 /-1.2 years (mean /-s.d.)), the A and S alleles were determined using PCR with a mismatched primer and the restriction enzyme BsaHI. BMD (g/cm) of the total body, humerus, femoral neck and lumbar spine was measured using dual energy X-ray absorptiometry. The genotype frequencies were 71% AA, 26% AS and 3% SS. The genotypes were divided into presence (29%) or absence of S allele (71%). Subjects with the S allele had higher levels of plasma calcium, corrected for albumin (2.17 /-0.06&gt;2.14 /-0.06; P &lt; 0.05, using independent samples t-test), lower BMD at the lumbar spine (P=0.02) and total body (P=0.04), and were significantly less physically active (2.9 /-2.6 vs 4.3 /-2.6 h/week; P=0.01) than the subjects lacking the S allele. [[PTH]] levels were not significantly different between the two allelic groups. A multiple regression analysis, including age, height, weight and physical activity, revealed that the [[CASR]] allelic variants were not independent predictors of BMD at any site measured (beta=-0.03-0.09; P&gt;0.05). Physical activity was an independent predictor of BMD, was significantly different between the [[CASR]] genotypes, and could therefore have a role in explaining the difference in BMD between the [[CASR]] genotypes. The [[CASR]] alleles are related to BMD, but it cannot be definitely concluded whether the [[CASR]] polymorphism has a direct influence on BMD, or whether the differences in BMD were mediated via an influence of the amount of physical activity.<br /> |mesh-terms=* Absorptiometry, Photon<br /> * Adolescent<br /> * Aging<br /> * Alleles<br /> * Body Height<br /> * Body Weight<br /> * Bone Density<br /> * Calcium<br /> * European Continental Ancestry Group<br /> * Female<br /> * Femur Neck<br /> * Gene Frequency<br /> * Genotype<br /> * Health<br /> * Humans<br /> * Humerus<br /> * Lumbar Vertebrae<br /> * Menarche<br /> * Osteocalcin<br /> * Parathyroid Hormone<br /> * Physical Exertion<br /> * Polymerase Chain Reaction<br /> * Polymorphism, Genetic<br /> * Receptors, Calcium-Sensing<br /> * Receptors, Cell Surface<br /> <br /> |full-text-url=https://sci-hub.do/10.1530/eje.0.1440257<br /> }}</div>

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