https://transhumanist.ru/index.php?action=history&feed=atom&title=CADM2CADM2 - История изменений2026-06-22T07:44:07ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=CADM2&diff=4231&oldid=prevOdysseusBot: Новая страница: «Cell adhesion molecule 2 precursor (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2)...»2021-04-29T19:07:29Z<p>Новая страница: «Cell adhesion molecule 2 precursor (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2)...»</p>
<p><b>Новая страница</b></p><div>Cell adhesion molecule 2 precursor (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2) [IGSF4D] [NECL3]<br />
<br />
==Publications==<br />
<br />
{{medline-entry<br />
|title=GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25199915<br />
|abstract=The genetic contribution to longevity in humans has been estimated to range from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with longevity in multiple independent studies. We conducted a meta-analysis of genome-wide association studies including 6,036 longevity cases, age ≥90 years, and 3,757 controls that died between ages 55 and 80 years. We additionally attempted to replicate earlier identified single nucleotide polymorphism (SNP) associations with longevity. In our meta-analysis, we found suggestive evidence for the association of SNPs near [[CADM2]] (odds ratio [OR] = 0.81; p value = 9.66 × 10(-7)) and GRIK2 (odds ratio = 1.24; p value = 5.09 × 10(-8)) with longevity. When attempting to replicate findings earlier identified in genome-wide association studies, only the APOE locus consistently replicated. In an additional look-up of the candidate gene FOXO3, we found that an earlier identified variant shows a highly significant association with longevity when including published data with our meta-analysis (odds ratio = 1.17; p value = 1.85×10(-10)). We did not identify new genome-wide significant associations with longevity and did not replicate earlier findings except for APOE and FOXO3. Our inability to find new associations with survival to ages ≥90 years because longevity represents multiple complex traits with heterogeneous genetic underpinnings, or alternatively, that longevity may be regulated by rare variants that are not captured by standard genome-wide genotyping and imputation of common variants.<br />
|mesh-terms=* Aged<br />
* Aged, 80 and over<br />
* Apolipoproteins E<br />
* Cell Adhesion Molecules<br />
* Cohort Studies<br />
* Female<br />
* Forkhead Box Protein O3<br />
* Forkhead Transcription Factors<br />
* Genome-Wide Association Study<br />
* Humans<br />
* Longevity<br />
* Male<br />
* Middle Aged<br />
* Polymorphism, Single Nucleotide<br />
* Receptors, Kainic Acid<br />
|keywords=* APOE.<br />
* FOXO3<br />
* GWAS<br />
* Longevity<br />
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296168<br />
}}</div>OdysseusBot