https://transhumanist.ru/index.php?action=history&feed=atom&title=CADM1 2026-11-08T06:22:18Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CADM1&diff=5136&oldid=prev 2021-05-12T13:30:46Z

<p>Новая страница: «Cell adhesion molecule 1 precursor (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIg...»</p> <p><b>Новая страница</b></p><div>Cell adhesion molecule 1 precursor (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1) [IGSF4] [IGSF4A] [NECL2] [SYNCAM] [TSLC1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Role of [[CRTAM]] during mouse early T lymphocytes development.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19799932<br /> |abstract=[[CRTAM]] was reported as a novel receptor expressed in activated NKT and CD8 T lymphocytes. However, we have recently shown that it is also expressed in several non-immune tissues. In opposition to what has been stated for lymphoid cells, [[CRTAM]] expression is constitutive in epithelia, suggesting a role in cell-cell interactions. Given the importance of cell interactions during T lymphocyte development, we evaluated [[CRTAM]] during T lymphocyte ontogeny. Here we show that [[CRTAM]] has an unexpected constitutive expression in adult thymocytes and, remarkably, it is sustained during all stages of thymocyte development. [[CRTAM]] expression is restricted to CD8 and all DN subpopulations, with a consistent pattern from E13.5 stage to adult mice. Blocking [[CRTAM]] interaction with [[CADM1]] impairs thymus growth, uncovering a novel role in thymus development, with a consequent impact in thymocyte maturation. Thus, [[CRTAM]] interaction with [[CADM1]] is involved in structural maintenance of the thymic lobes.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Cell Differentiation<br /> * Immunoglobulins<br /> * Mice<br /> * Mice, Inbred C57BL<br /> * Rats<br /> * Rats, Sprague-Dawley<br /> * T-Lymphocytes<br /> * Thymus Gland<br /> * Tissue Culture Techniques<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.dci.2009.09.009<br /> }}</div>

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