https://transhumanist.ru/index.php?action=history&feed=atom&title=CACNA2D1 2026-04-21T02:18:15Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=CACNA2D1&diff=4623&oldid=prev 2021-04-29T19:26:55Z

<p>Новая страница: «Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor (Voltage-gated calcium channel subunit alpha-2/delta-1) [Contains: Voltage-dependent calcium c...»</p> <p><b>Новая страница</b></p><div>Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor (Voltage-gated calcium channel subunit alpha-2/delta-1) [Contains: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] [CACNL2A] [CCHL2A] [MHS3]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Pregabalin can prevent, but not treat, cognitive dysfunction following abdominal surgery in aged rats.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26872983<br /> |abstract=The present study aimed to explore the preventive or therapeutic effect of peri-operative pregabalin treatment on the memory deficits and related hippocampal inflammation following surgery in aged rats. Aged rats underwent abdominal or sham surgery, and were then divided into 2 groups, either early or late pregabalin treatment. Fourteen days after surgery, the cognitive function was assessed using novel object recognition test, followed by measurement of hippocampal cytokines and voltage-dependent calcium channel α2δ subunit ([[CACNA2D1]]). The parabiotic experiments determined whether the humoral or neuronal pathway was involved in the neuroinflammation development following the abdominal surgery. The effects of pregabalin on LPS-induced cytokine release from hippocampal microglia were also evaluated. Early pregabalin treatment, which was administered pre-operatively and continued for 3 or 7days after surgery, prevented memory deficits and decreased hippocampal pro-inflammatory cytokine levels. In contrast, no beneficial effects were observed when pregabalin was administered late in the post-operative period. The hippocampal levels of [[CACNA2D1]] did not change under any experimental condition. The data from the cross-circulation (parabiosis) experiments indicated that abdominal surgery may induce neuroinflammation via a neural transmission pathway from the periphery to the brain. The ex vivo experiments further demonstrated that pregabalin had no effect on LPS-induced cytokines release from hippocampal microglia. Our findings highlight reveal that peri-operative pregabalin treatment during the early post-operative period can prevent neuroinflammation and memory deficits after surgery. It is likely this occurs through a peripheral and central neuro-immune interaction rather than through direct anti-inflammatory effects.<br /> |mesh-terms=* Abdominal Muscles<br /> * Aging<br /> * Animals<br /> * Cognition Disorders<br /> * Male<br /> * Postoperative Complications<br /> * Pregabalin<br /> * Preoperative Care<br /> * Rats<br /> * Rats, Wistar<br /> * Treatment Outcome<br /> |keywords=* Microglia<br /> * Neuroinflammation<br /> * Post-operative cognitive dysfunction<br /> |full-text-url=https://sci-hub.do/10.1016/j.lfs.2016.02.021<br /> }}</div>

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