https://transhumanist.ru/index.php?action=history&feed=atom&title=C2CD2 2026-06-13T18:01:19Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=C2CD2&diff=6018&oldid=prev 2021-05-12T15:06:02Z

<p>Новая страница: «C2 domain-containing protein 2 (Transmembrane protein 24-like) [C21orf25] [C21orf258] [TMEM24L] ==Publications== {{medline-entry |title=Genetic variants associa...»</p> <p><b>Новая страница</b></p><div>C2 domain-containing protein 2 (Transmembrane protein 24-like) [C21orf25] [C21orf258] [TMEM24L]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Genetic variants associated with physical performance and anthropometry in old age: a genome-wide association study in the ilSIRENTE cohort.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29158487<br /> |abstract=Unraveling the complexity of aging is crucial for understanding its mechanisms and its role as a risk factor for most chronic conditions. Advancements marked by genome-wide association studies (GWASs) have sparked interest in gene cataloguing in the context of aging and age-related conditions. Here, we used GWAS to explore whether single nucleotide polymorphisms (SNPs) were associated with functional and anthropometric parameters in a cohort of old community-dwellers enrolled in the ilSIRENTE study. Analyses were carried out in men and women aged 80 years enrolled in the ilSIRENTE study (n = 286) and replicated in the inCHIANTI study (n = 1055). Genotyping was accomplished on Infinium Human610-QUAD version 1. In the ilSIRENTE population, genetic variants in ZNF295 and [[C2CD2]] (rs928874 and rs1788355) on chromosome 21q22.3, were significantly associated with the 4-meter gait speed (rs928874, p = 5.61 × 10 ; rs1788355, p = 5.73 × 10 ). This association was not replicated in the inCHIANTI population. Our findings suggest that specific SNPs may be associated with a key measure of physical performance in older adults. GWASs using larger samples are needed to confirm these preliminary results to enhance our comprehension of complex age-associated phenomena.<br /> |mesh-terms=* Aged<br /> * Aged, 80 and over<br /> * Aging<br /> * Anthropometry<br /> * DNA-Binding Proteins<br /> * Female<br /> * Genetic Predisposition to Disease<br /> * Genome-Wide Association Study<br /> * Genotype<br /> * Humans<br /> * Male<br /> * Membrane Proteins<br /> * Physical Functional Performance<br /> * Polymorphism, Single Nucleotide<br /> * Transcription Factors<br /> * Walking Speed<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696534<br /> }}</div>

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