https://transhumanist.ru/index.php?action=history&feed=atom&title=BTG4BTG4 - История изменений2026-06-22T18:15:06ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=BTG4&diff=4247&oldid=prevOdysseusBot: Новая страница: «Protein BTG4 (BTG family member 4) (Protein PC3b) [PC3B] ==Publications== {{medline-entry |title=Age-related decrease of IF5/BTG4 in oral and respiratory ca...»2021-04-29T19:08:20Z<p>Новая страница: «Protein BTG4 (BTG family member 4) (Protein PC3b) [PC3B] ==Publications== {{medline-entry |title=Age-related decrease of IF5/<a href="/BTG4" title="BTG4">BTG4</a> in oral and respiratory ca...»</p>
<p><b>Новая страница</b></p><div>Protein BTG4 (BTG family member 4) (Protein PC3b) [PC3B]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Age-related decrease of IF5/[[BTG4]] in oral and respiratory cavities in mice.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25660503<br />
|abstract=An IF5 cDNA was isolated by expression cloning from a mouse oocyte cDNA library. It encoded a protein of 250 amino acids, and the region of it encoding amino acids 1-137 showed 86.8% alignment with the anti-proliferative domain of BTG/TOB family genes. This gene is also termed [[BTG4]] or PC3B. Transiently expressed IF5/[[BTG4]] induced alkaline phosphatase activity in human embryonic kidney (HEK293T) and 2T3 cells. IF5/[[BTG4]] mRNA was detected by reverse transcription polymerase chain reaction in pharynx, larynx, trachea, oviduct, ovary, caput epididymis, and testis, but not in lung, intestine, or liver. Immunohistochemistry showed the IF5/[[BTG4]] protein to be present in epithelial cells of the tongue, palate, pharynx, internal nose, and trachea. Both protein and mRNA levels of IF5/[[BTG4]] were reduced by aging when comparing 4-week-old mice with 48-week-old mice. Our findings suggest that IF5/[[BTG4]] may be an aging-related gene in epithelial cells. <br />
|mesh-terms=* Aging<br />
* Alkaline Phosphatase<br />
* Amino Acid Sequence<br />
* Animals<br />
* Base Sequence<br />
* Cell Cycle Proteins<br />
* Cell Differentiation<br />
* Cell Proliferation<br />
* Cloning, Molecular<br />
* Down-Regulation<br />
* Epithelial Cells<br />
* Female<br />
* HEK293 Cells<br />
* Humans<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* Molecular Sequence Data<br />
* Mouth<br />
* Nasal Cavity<br />
* RNA, Messenger<br />
* Trachea<br />
|keywords=* IF5/BTG4<br />
* aging<br />
* epithelium<br />
* oral<br />
* respiratory<br />
|full-text-url=https://sci-hub.do/10.1080/09168451.2015.1008976<br />
}}</div>OdysseusBot