https://transhumanist.ru/index.php?action=history&feed=atom&title=BPI 2026-04-05T21:36:15Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=BPI&diff=6004&oldid=prev 2021-05-12T15:05:19Z

<p>Новая страница: «Bactericidal permeability-increasing protein precursor (BPI) (CAP 57) ==Publications== {{medline-entry |title=High TARC plasma levels confer protection to long...»</p> <p><b>Новая страница</b></p><div>Bactericidal permeability-increasing protein precursor (BPI) (CAP 57)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=High TARC plasma levels confer protection to long living individuals by inducing M2 profile.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002742<br /> |abstract=A way to delay aging and the related low-grade chronic inflammatory state is to study the model of positive physiology such as the Long-Living Individuals (LLIs). Our recent studies have shown higher levels of the host defense [[BPI]] Fold-Containing Family B Member 4 ([[BPI]]FB4) protein in the LLIs&#039; blood. Notably, [[BPI]]FB4 has been shown to influence monocytes typesetting and M2 anti-inflammatory phenotype (CD206 CD163 ) macrophages skewing. According to the role of a complex cytokine milieu in guiding the macrophage polarization, here we found that circulating concentrations of thymus and activation regulated chemokine (TARC)/CCL17 and small-inducible cytokine B10 (IP-10)/CXCL10) cytokines, were additionally associated with the LLIs&#039; state. In a differentiation process in vitro, the addition of LLIs&#039; plasma to the cell culture medium, enhanced the ability of monocytes, either from LLIs or controls, to acquire a M2 phenotype. Interestingly, a neutralizing antibody against TARC blunted the M2 skewing effect of the LLIs&#039; plasma. Collectively, these data indicate that exceptional longevity may associate with a peculiar anti-inflammatory myeloid profile responsible for improved reparative processes and reduced inflammatory status mediated in part by TARC and M2 generation.<br /> <br /> |keywords=* FACS<br /> * Longevity<br /> * M2 macrophages<br /> * Plasma profile<br /> * TARC<br /> |full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155305<br /> }}<br /> {{medline-entry<br /> |title=Circulating [[BPI]]FB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32547549<br /> |abstract=Long-Living Individuals (LLIs) delay aging and are less prone to chronic inflammatory reactions. Whether a distinct monocytes and macrophages repertoire is involved in such a characteristic remains unknown. Previous studies from our group have shown high levels of the host defense [[BPI]] Fold Containing Family B Member 4 ([[BPI]]FB4) protein in the peripheral blood of LLIs. Moreover, a polymorphic variant of the [i][[BPI]]FB4[/i] gene associated with exceptional longevity ([i]LAV-[[BPI]]FB4[/i]) confers protection from cardiovascular diseases underpinned by low-grade chronic inflammation, such as atherosclerosis. We hypothesize that [[BPI]]FB4 may influence monocytes pool and macrophages skewing, shifting the balance toward an anti-inflammatory phenotype. We profiled circulating monocytes in 52 LLIs (median-age 97) and 52 healthy volunteers (median-age 55) using flow cytometry. If the frequency of total monocyte did not change, the intermediate CD14 CD16 monocytes counts were lower in LLIs compared to control adults. Conversely, non-classical CD14 CD16 monocyte counts, which are M2 macrophage precursors with an immunomodulatory function, were found significantly associated with the LLIs&#039; state. In a differentiation assay, supplementation of the LLIs&#039; plasma enhanced the capacity of monocytes, either from LLIs or controls, to acquire a paracrine M2 phenotype. A neutralizing antibody against the phosphorylation site (ser 75) of [[BPI]]FB4 blunted the M2 skewing effect of the LLIs&#039; plasma. These data indicate that LLIs carry a peculiar anti-inflammatory myeloid profile, which is associated with and possibly sustained by high circulating levels of [[BPI]]FB4. Supplementation of recombinant [[BPI]]FB4 may represent a novel means to attenuate inflammation-related conditions typical of unhealthy aging.<br /> <br /> |keywords=* FACS<br /> * M2 macrophages<br /> * immunity<br /> * longevity<br /> * patrolling-monocytes<br /> * plasma<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272600<br /> }}<br /> {{medline-entry<br /> |title=The effect of postural deformities on back function and pain in patients with Parkinson&#039;s disease.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31177242<br /> |abstract=Postural deformities, such as Pisa syndrome (PS), and camptocormia and antecollis (C</div>

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