https://transhumanist.ru/index.php?action=history&feed=atom&title=BLVRA 2026-06-08T03:47:34Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=BLVRA&diff=5991&oldid=prev 2021-05-12T15:04:36Z

<p>Новая страница: «Biliverdin reductase A precursor (EC 1.3.1.24) (BVR A) (Biliverdin-IX alpha-reductase) [BLVR] [BVR] ==Publications== {{medline-entry |title=Attenuation of epige...»</p> <p><b>Новая страница</b></p><div>Biliverdin reductase A precursor (EC 1.3.1.24) (BVR A) (Biliverdin-IX alpha-reductase) [BLVR] [BVR]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Attenuation of epigenetic regulator [[SMARCA4]] and ERK-ETS signaling suppresses aging-related dopaminergic degeneration.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32749068<br /> |abstract=How complex interactions of genetic, environmental factors and aging jointly contribute to dopaminergic degeneration in Parkinson&#039;s disease (PD) is largely unclear. Here, we applied frequent gene co-expression analysis on human patient substantia nigra-specific microarray datasets to identify potential novel disease-related genes. In vivo Drosophila studies validated two of 32 candidate genes, a chromatin-remodeling factor [[SMARCA4]] and a biliverdin reductase [[BLVRA]]. Inhibition of [[SMARCA4]] was able to prevent aging-dependent dopaminergic degeneration not only caused by overexpression of [[BLVRA]] but also in four most common Drosophila PD models. Furthermore, down-regulation of [[SMARCA4]] specifically in the dopaminergic neurons prevented shortening of life span caused by α-synuclein and [[LRRK2]]. Mechanistically, aberrant [[SMARCA4]] and [[BLVRA]] converged on elevated ERK-ETS activity, attenuation of which by either genetic or pharmacological manipulation effectively suppressed dopaminergic degeneration in Drosophila in vivo. Down-regulation of [[SMARCA4]] or drug inhibition of MEK/ERK also mitigated mitochondrial defects in [[PINK1]] (a PD-associated gene)-deficient human cells. Our findings underscore the important role of epigenetic regulators and implicate a common signaling axis for therapeutic intervention in normal aging and a broad range of age-related disorders including PD.<br /> <br /> |keywords=* <br /> Drosophila<br /> <br /> * MAPK-ERK-ETS signaling<br /> * Parkinson&#039;s disease<br /> * SMARCA4/Brahma<br /> * aging<br /> * neurodegeneration<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511865<br /> }}</div>

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