https://transhumanist.ru/index.php?action=history&feed=atom&title=BLNKBLNK - История изменений2026-06-01T03:52:52ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=BLNK&diff=5191&oldid=prevOdysseusBot: Новая страница: «B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (...»2021-05-12T13:33:22Z<p>Новая страница: «B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (...»</p>
<p><b>Новая страница</b></p><div>B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) [BASH] [SLP65]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Requirement for B cell linker protein ([[BLNK]]) in B cell development.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/10583957<br />
|abstract=Linker proteins function as molecular scaffolds to localize enzymes with substrates. In B cells, B cell linker protein ([[BLNK]]) links the B cell receptor ([[BCR]])-activated Syk kinase to the phosphoinositide and mitogen-activated kinase pathways. To examine the in vivo role of [[BLNK]], mice deficient in [[BLNK]] were generated. B cell development in [[BLNK]]-/- mice was blocked at the transition from B220 CD43 progenitor B to B220 CD43- precursor B cells. Only a small percentage of immunoglobulin M (IgM ), but not mature IgMloIgDhi, B cells were detected in the periphery. Hence, [[BLNK]] is an essential component of [[BCR]] signaling pathways and is required to promote B cell development.<br />
|mesh-terms=* Adaptor Proteins, Signal Transducing<br />
* Aging<br />
* Animals<br />
* B-Lymphocyte Subsets<br />
* B-Lymphocytes<br />
* Bone Marrow Cells<br />
* Carrier Proteins<br />
* Cell Count<br />
* Cell Differentiation<br />
* Cell Separation<br />
* Cell Size<br />
* Flow Cytometry<br />
* Gene Targeting<br />
* Hematopoietic Stem Cells<br />
* Immunoglobulin M<br />
* Leukopoiesis<br />
* Lymphoid Tissue<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* Phosphoproteins<br />
* Receptors, Antigen, B-Cell<br />
* Second Messenger Systems<br />
* Signal Transduction<br />
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|full-text-url=https://sci-hub.do/10.1126/science.286.5446.1949<br />
}}</div>OdysseusBot