https://transhumanist.ru/index.php?action=history&feed=atom&title=BICD2BICD2 - История изменений2026-06-11T08:53:06ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=BICD2&diff=5179&oldid=prevOdysseusBot: Новая страница: «Protein bicaudal D homolog 2 (Bic-D 2) [KIAA0699] ==Publications== {{medline-entry |title=A novel mouse model with impaired dynein/dynactin function develops am...»2021-05-12T13:32:52Z<p>Новая страница: «Protein bicaudal D homolog 2 (Bic-D 2) [KIAA0699] ==Publications== {{medline-entry |title=A novel mouse model with impaired dynein/dynactin function develops am...»</p>
<p><b>Новая страница</b></p><div>Protein bicaudal D homolog 2 (Bic-D 2) [KIAA0699]<br />
<br />
==Publications==<br />
<br />
{{medline-entry<br />
|title=A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in [[SOD1]]-ALS mice.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18579581<br />
|abstract=Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by progressive motor neuron degeneration and muscle paralysis. Genetic evidence from man and mouse has indicated that mutations in the dynein/dynactin motor complex are correlated with motor neuron degeneration. In this study, we have generated transgenic mice with neuron-specific expression of Bicaudal D2 N-terminus ([[BICD2]]-N) to chronically impair dynein/dynactin function. Motor neurons expressing [[BICD2]]-N showed accumulation of dynein and dynactin in the cell body, Golgi fragmentation and several signs of impaired retrograde trafficking: the appearance of giant neurofilament swellings in the proximal axon, reduced retrograde labelling by tracer injected in the muscle and delayed expression of the injury transcription factor [[ATF3]] after axon transection. Despite these abnormalities, [[BICD2]]-N mice did not develop signs of motor neuron degeneration and motor abnormalities. Interestingly, the [[BICD2]]-N transgene increased lifespan in 'low copy' [[SOD1]]-G93A ALS transgenic mice. Our findings indicate that impaired dynein/dynactin function can explain several pathological features observed in ALS patients, but may be beneficial in some forms of ALS.<br />
|mesh-terms=* Amyotrophic Lateral Sclerosis<br />
* Animals<br />
* Biological Transport<br />
* Carrier Proteins<br />
* Cells, Cultured<br />
* Disease Models, Animal<br />
* Dynactin Complex<br />
* Dyneins<br />
* Female<br />
* Gene Expression<br />
* Golgi Apparatus<br />
* Humans<br />
* Life Expectancy<br />
* Male<br />
* Membrane Proteins<br />
* Mice<br />
* Mice, Transgenic<br />
* Microtubule-Associated Proteins<br />
* Motor Neurons<br />
* Rats<br />
* Superoxide Dismutase<br />
* Superoxide Dismutase-1<br />
* Survival<br />
<br />
|full-text-url=https://sci-hub.do/10.1093/hmg/ddn182<br />
}}</div>OdysseusBot