https://transhumanist.ru/index.php?action=history&feed=atom&title=BICD1BICD1 - История изменений2026-08-19T20:57:41ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=BICD1&diff=4581&oldid=prevOdysseusBot: Новая страница: «Protein bicaudal D homolog 1 (Bic-D 1) ==Publications== {{medline-entry |title=Kidney Allograft Telomere Length Is Not Associated with Sex, Recipient Comorbid C...»2021-04-29T19:25:03Z<p>Новая страница: «Protein bicaudal D homolog 1 (Bic-D 1) ==Publications== {{medline-entry |title=Kidney Allograft Telomere Length Is Not Associated with Sex, Recipient Comorbid C...»</p>
<p><b>Новая страница</b></p><div>Protein bicaudal D homolog 1 (Bic-D 1)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Kidney Allograft Telomere Length Is Not Associated with Sex, Recipient Comorbid Conditions, Post-Transplant Infections, or CMV Reactivation.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27350315<br />
|abstract=BACKGROUND Immunosenescence is closely linked to chromosome telomere erosion and telomerase activity alterations. The aim of this study was to analyze the associations of relative telomere length (RTL) of a graft with sex, comorbid conditions, post-transplant infections, and CMV reactivation among transplanted kidney recipients. Additionally, the associations of donor and recipient hTERT, [[BICD1]] genes and chromosome 18 polymorphisms with post-transplant infections were analyzed, including the analysis of donor-recipient genotype pairs. MATERIAL AND METHODS The study enrolled 119 white Polish kidney allograft recipients (64M/55F, mean age 47.3±14.0). The RTL was assessed by modification of a method developed by Cawthon, using a qPCR system. To identify genotypes of the studied polymorphisms, real-time PCR was performed. RESULTS There were no significant associations between graft RTL and sex of donor and recipient, comorbid DM and AH, as well as post-transplant infections and CMV reactivation. There were no statistically significant differences in distribution of hTERT, [[BICD1]] genes and chromosome 18 graft and recipient polymorphisms genotypes between individuals with post-transplant infection and those without infection. The rs2735940 CX-TT hTERT gene donor-recipient genotypes combination was associated with higher risk of post-transplant infection on the border of statistical significance (OR=4.632, 95%CI (0.853-25.14); p=0.067). CONCLUSIONS Assessment of kidney allograft RTL does not show its association with sex, DM, AH, post-transplant infection, or CMV reactivation in the recipients, suggesting that other factors, probably directly related to the transplantation procedure, have a greater effect on telomere length. <br />
|mesh-terms=* Adaptor Proteins, Signal Transducing<br />
* Adult<br />
* Allografts<br />
* Cytomegalovirus Infections<br />
* Cytoskeletal Proteins<br />
* Female<br />
* Humans<br />
* Immunosenescence<br />
* Kidney Transplantation<br />
* Male<br />
* Middle Aged<br />
* Polymorphism, Single Nucleotide<br />
* Sex Factors<br />
* Telomerase<br />
* Telomere<br />
* Virus Activation<br />
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|full-text-url=https://sci-hub.do/10.12659/aot.898007<br />
}}</div>OdysseusBot