https://transhumanist.ru/index.php?action=history&feed=atom&title=BCAS1 2026-06-03T15:40:04Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=BCAS1&diff=5978&oldid=prev 2021-05-12T15:03:33Z

<p>Новая страница: «Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) [AIBC1] [NABC1] ==Publications== {{med...»</p> <p><b>Новая страница</b></p><div>Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) [AIBC1] [NABC1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Hallmarks of the cancer cell of origin: Comparisons with &quot;energetic&quot; cancer stem cells (e-CSCs).<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30760648<br /> |abstract=Here, we discuss the expected hallmark(s) of the cancer cell of origin and how this may be related to a new tumor cell phenotype, namely &quot;energetic&quot; cancer stem cells (e-CSCs). e-CSCs show many features that would be characteristic of the cancer cell of origin, including the over-expression of p21-WAF (CDKN1A), a key marker of senescence. It is tempting to speculate that the cancer cell of origin and e-CSCs are closely related entities. e-CSCs possess a hybrid phenotype, sharing key hallmarks of senescence, &quot;stemness&quot; and cancer. e-CSCs are hyper-proliferative and have elevated mitochondrial metabolism, with an NRF2-mediated anti-oxidant response signature, including glutaredoxin (GLRX) and [[ALDH3A1]] over-expression, possibly related to their escape from senescence. Finally, in e-CSCs, [[BCAS1]] (Breast carcinoma-amplified sequence-1) protein expression was up-regulated by &gt;100-fold. [[BCAS1]] is a candidate oncogene associated with &quot;stemness&quot; and aggressive oncogenic behavior, such as Tamoxifen resistance.<br /> |mesh-terms=* Humans<br /> * Neoplasms<br /> * Neoplastic Stem Cells<br /> |keywords=* anti-oxidant response<br /> * cancer cell of origin<br /> * cancer stem cells (CSCs)<br /> * metabolism<br /> * senescence<br /> * tamoxifen resistance<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382415<br /> }}</div>

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