https://transhumanist.ru/index.php?action=history&feed=atom&title=BAZ2BBAZ2B - История изменений2026-06-07T09:44:41ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=BAZ2B&diff=5977&oldid=prevOdysseusBot: Новая страница: «Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) [KIAA1476] ==Publications== {{medline-entry |title=Two conserved epigenetic regulators prevent he...»2021-05-12T15:03:29Z<p>Новая страница: «Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) [KIAA1476] ==Publications== {{medline-entry |title=Two conserved epigenetic regulators prevent he...»</p>
<p><b>Новая страница</b></p><div>Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) [KIAA1476]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Two conserved epigenetic regulators prevent healthy ageing.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32103178<br />
|abstract=It has long been assumed that lifespan and healthspan correlate strongly, yet the two can be clearly dissociated . Although there has been a global increase in human life expectancy, increasing longevity is rarely accompanied by an extended healthspan . Thus, understanding the origin of healthy behaviours in old people remains an important and challenging task. Here we report a conserved epigenetic mechanism underlying healthy ageing. Through genome-wide RNA-interference-based screening of genes that regulate behavioural deterioration in ageing Caenorhabditis elegans, we identify 59 genes as potential modulators of the rate of age-related behavioural deterioration. Among these modulators, we found that a neuronal epigenetic reader, BAZ-2, and a neuronal histone 3 lysine 9 methyltransferase, [[SET]]-6, accelerate behavioural deterioration in C. elegans by reducing mitochondrial function, repressing the expression of nuclear-encoded mitochondrial proteins. This mechanism is conserved in cultured mouse neurons and human cells. Examination of human databases shows that expression of the human orthologues of these C. elegans regulators, [[BAZ2B]] and [[EHMT1]], in the frontal cortex increases with age and correlates positively with the progression of Alzheimer's disease. Furthermore, ablation of Baz2b, the mouse orthologue of BAZ-2, attenuates age-dependent body-weight gain and prevents cognitive decline in ageing mice. Thus our genome-wide RNA-interference screen in C. elegans has unravelled conserved epigenetic negative regulators of ageing, suggesting possible ways to achieve healthy ageing.<br />
|mesh-terms=* Aging<br />
* Animals<br />
* Caenorhabditis elegans<br />
* Caenorhabditis elegans Proteins<br />
* Cognition<br />
* Cognitive Dysfunction<br />
* Epigenesis, Genetic<br />
* Healthy Aging<br />
* Histone-Lysine N-Methyltransferase<br />
* Histones<br />
* Humans<br />
* Longevity<br />
* Lysine<br />
* Male<br />
* Memory<br />
* Methylation<br />
* Mice<br />
* Mitochondria<br />
* Neurons<br />
* Proteins<br />
* RNA Interference<br />
* Spatial Learning<br />
* Transcription Factors, General<br />
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|full-text-url=https://sci-hub.do/10.1038/s41586-020-2037-y<br />
}}</div>OdysseusBot