https://transhumanist.ru/index.php?action=history&feed=atom&title=BAALC 2026-06-18T17:57:59Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=BAALC&diff=5966&oldid=prev 2021-05-12T15:02:56Z

<p>Новая страница: «Brain and acute leukemia cytoplasmic protein ==Publications== {{medline-entry |title=Relation of <a href="/BAALC" title="BAALC">BAALC</a> and <a href="/ERG" title="ERG">ERG</a> Gene Expression with Overall Survival in...»</p> <p><b>Новая страница</b></p><div>Brain and acute leukemia cytoplasmic protein<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Relation of [[BAALC]] and [[ERG]] Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26625814<br /> |abstract=The objectives of this study were to evaluate the expression of brain and acute leukemia, cytoplasmic ([[BAALC]]) gene and erythroblast transformation-specific related gene ([[ERG]]) in de novo cases of acute myeloid leukemia (AML) and identify roles in disease progression and outcome. This study included 50 newly diagnosed AML patients, along with 10 apparently healthy normal controls. [[BAALC]] and [[ERG]] expression was detected in the bone marrow of both patients and controls using real-time RT-PCR. [[BAALC]] and [[ERG]] expression was detected in 52% of cases but not in any controls. There was a statistically significant correlation between [[BAALC]] and [[ERG]] gene expression and age (p- value=0.004 and 0.019, respectively). No statistical significance was noted for sex, lymphadenopathy, hepatomegaly, splenomegaly, other hematological findings, immunophenotyping and FAB sub-classification except for [[ERG]] gene and FAB (p-value=0.058). A statistical significant correlation was found between response to treatment with [[ERG]] expression (p-value=0.028) and age (p-value=0.014). A statistically significant variation in overall survival was evident with patient age, BM blast cells, FAB subgroups, [[BAALC]] and [[ERG]] expression (p-value= &lt;0.001, 0.045, 0.041, &lt;0.008 and 0.025 respectively). Our results suggest that [[BAALC]] and [[ERG]] genes are specific significant molecular markers in AML disease progression, response to treatment and survival.<br /> |mesh-terms=* Adult<br /> * Aging<br /> * Biomarkers, Tumor<br /> * Bone Marrow<br /> * Bone Marrow Cells<br /> * Disease Progression<br /> * Egypt<br /> * Female<br /> * Gene Expression Profiling<br /> * Humans<br /> * Leukemia, Myeloid, Acute<br /> * Male<br /> * Middle Aged<br /> * Neoplasm Proteins<br /> * Trans-Activators<br /> * Transcriptional Regulator ERG<br /> * Treatment Outcome<br /> <br /> |full-text-url=https://sci-hub.do/10.7314/apjcp.2015.16.17.7875<br /> }}</div>

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