https://transhumanist.ru/index.php?action=history&feed=atom&title=ASB7 2026-06-03T08:55:22Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ASB7&diff=5930&oldid=prev 2021-05-12T15:00:55Z

<p>Новая страница: «Ankyrin repeat and SOCS box protein 7 (ASB-7) ==Publications== {{medline-entry |title=<a href="/ASB7" title="ASB7">ASB7</a> Is a Novel Regulator of Cytoskeletal Organization During Oocyte M...»</p> <p><b>Новая страница</b></p><div>Ankyrin repeat and SOCS box protein 7 (ASB-7)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[ASB7]] Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251222<br /> |abstract=Ankyrin repeat and SOCS box (ASB) family members have a [i]C[/i]-terminal SOCS box and an [i]N[/i]-terminal ankyrin-related sequence of variable repeats. To date, the roles of ASB family members remain largely unknown. In the present study, by employing knockdown analysis, we investigated the effects of [[ASB7]] on mouse oocyte meiosis. We show that specific depletion of [[ASB7]] disrupts maturational progression and meiotic apparatus. In particular, abnormal spindle, misaligned chromosomes, and loss of cortical actin cap are frequently observed in [[ASB7]]-abated oocytes. Consistent with this observation, incidence of aneuploidy is increased in these oocytes. Meanwhile, confocal scanning reveals that loss of [[ASB7]] impairs kinetochore-microtubule interaction and provokes the spindle assembly checkpoint during oocyte meiosis. Furthermore, we find a significant reduction of [[ASB7]] protein in oocytes from aged mice. Importantly, increasing [[ASB7]] expression is capable of partially rescuing the maternal age-induced meiotic defects in oocytes. Together, our data identify [[ASB7]] as a novel player in regulating cytoskeletal organization and discover the potential effects of [[ASB7]] on quality control of aging oocytes.<br /> <br /> |keywords=* ASBs<br /> * maternal aging<br /> * meiosis<br /> * oocyte<br /> * reproduction<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674779<br /> }}</div>

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