https://transhumanist.ru/index.php?action=history&feed=atom&title=ARIH2 2026-06-12T11:15:35Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ARIH2&diff=5918&oldid=prev 2021-05-12T15:00:12Z

<p>Новая страница: «E3 ubiquitin-protein ligase ARIH2 (EC 2.3.2.31) (ARI-2) (Protein ariadne-2 homolog) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein) [ARI2] [TRIAD1] [H...»</p> <p><b>Новая страница</b></p><div>E3 ubiquitin-protein ligase ARIH2 (EC 2.3.2.31) (ARI-2) (Protein ariadne-2 homolog) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein) [ARI2] [TRIAD1] [HT005]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=A novel feed-forward loop between [[ARIH2]] E3-ligase and [[PABPN1]] regulates aging-associated muscle degeneration.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24486325<br /> |abstract=Alanine expansion mutations in poly(A)-binding protein nuclear 1 ([[PABPN1]]) cause muscle weakness in the late-onset disorder oculopharyngeal muscular dystrophy. In affected muscles, expanded [[PABPN1]] forms nuclear aggregates, depleting levels of soluble [[PABPN1]] and inducing a genome-wide shift from distal to proximal polyadenylation site usage. [[PABPN1]] protein accumulation is regulated by the ubiquitin proteasome system, which is highly dysregulated in oculopharyngeal muscular dystrophy. We show that [[ARIH2]] E3-ligase regulates [[PABPN1]] protein accumulation and aggregation. Levels of [[ARIH2]] mRNA are regulated by [[PABPN1]] via proximal polyadenylation site usage. We demonstrate that masking the proximal polyadenylation site in [[ARIH2]] 3&#039; untranslated region by antisense oligonucleotides elevates the expression of [[ARIH2]] and [[PABPN1]] and restores myogenic defects that are induced by [[ARIH2]] or [[PABPN1]] down-regulation in cell culture. In vivo [[ARIH2]] mRNA levels significantly decrease from midlife in vastus lateralis muscles and highly correlate with muscle degeneration. We suggest that the expression of both genes is maintained by a feed-forward loop between mRNA stability regulated by [[PABPN1]] and protein turnover regulated by [[ARIH2]]. <br /> |mesh-terms=* Aging<br /> * Animals<br /> * Blotting, Western<br /> * Cell Line<br /> * Gene Expression Regulation<br /> * Humans<br /> * Immunohistochemistry<br /> * Immunoprecipitation<br /> * Muscle, Skeletal<br /> * Muscular Dystrophy, Oculopharyngeal<br /> * Oligonucleotide Array Sequence Analysis<br /> * Poly(A)-Binding Protein I<br /> * Reverse Transcriptase Polymerase Chain Reaction<br /> * Transfection<br /> * Ubiquitin-Protein Ligases<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.ajpath.2013.12.011<br /> }}</div>

OdysseusBot