https://transhumanist.ru/index.php?action=history&feed=atom&title=ARAP1 2026-09-06T03:33:38Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ARAP1&diff=5720&oldid=prev 2021-05-12T13:56:46Z

<p>Новая страница: «Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) [CENTD2] [KIAA0782] ==Publications== {{medline-entry |ti...»</p> <p><b>Новая страница</b></p><div>Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) [CENTD2] [KIAA0782]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Development of hypertension and kidney hypertrophy in transgenic mice overexpressing [[ARAP1]] gene in the kidney.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16801480<br /> |abstract=Angiotensin II regulates blood pressure via activation of the type 1 receptor. We previously identified a novel angiotensin II type 1 receptor-associated protein and demonstrated that it promotes receptor recycling to the plasma membrane. To delineate the pathophysiological function of the [[ARAP1]] in the kidneys, we generated transgenic mice that overexpress rat [[ARAP1]] cDNA specifically in proximal tubules and tested the hypothesis that proximal tubule-specific overexpression of [[ARAP1]] causes hypertension. Two lines of male transgenic mice, 650 and 670, displayed kidney-specific transgene expression. Systolic blood pressure was significantly elevated by</div>

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