https://transhumanist.ru/index.php?action=history&feed=atom&title=ANTXR2ANTXR2 - История изменений2026-05-14T09:22:33ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=ANTXR2&diff=5651&oldid=prevOdysseusBot: Новая страница: «Anthrax toxin receptor 2 precursor (Capillary morphogenesis gene 2 protein) (CMG-2) [CMG2] ==Publications== {{medline-entry |title=Anthrax toxin receptor 2-depe...»2021-05-12T13:53:48Z<p>Новая страница: «Anthrax toxin receptor 2 precursor (Capillary morphogenesis gene 2 protein) (CMG-2) [CMG2] ==Publications== {{medline-entry |title=Anthrax toxin receptor 2-depe...»</p>
<p><b>Новая страница</b></p><div>Anthrax toxin receptor 2 precursor (Capillary morphogenesis gene 2 protein) (CMG-2) [CMG2]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Anthrax toxin receptor 2-dependent lethal toxin killing in vivo.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17054395<br />
|abstract=Anthrax toxin receptors 1 and 2 ([[ANTXR1]] and [[ANTXR2]]) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal ion and PA residue D683 are critical for [[ANTXR1]]-PA binding. Since PA can bind to [[ANTXR2]] with reduced affinity in the absence of metal ions, we reasoned that D683 mutant forms of PA might specifically interact with [[ANTXR2]]. We show here that this is the case. The differential ability of [[ANTXR1]] and [[ANTXR2]] to bind D683 mutant PA proteins was mapped to nonconserved receptor residues at the binding interface with PA domain 2. Moreover, a D683K mutant form of PA that bound specifically to human and rat [[ANTXR2]] mediated killing of rats by anthrax lethal toxin, providing strong evidence for the physiological importance of [[ANTXR2]] in anthrax disease pathogenesis.<br />
|mesh-terms=* Animals<br />
* Anthrax<br />
* Antibodies, Bacterial<br />
* Antigens, Bacterial<br />
* Bacillus anthracis<br />
* Bacterial Toxins<br />
* Base Sequence<br />
* Humans<br />
* Longevity<br />
* Male<br />
* Membrane Proteins<br />
* Microfilament Proteins<br />
* Molecular Sequence Data<br />
* Neoplasm Proteins<br />
* Rats<br />
* Rats, Inbred F344<br />
* Receptors, Cell Surface<br />
* Receptors, Peptide<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617126<br />
}}</div>OdysseusBot