https://transhumanist.ru/index.php?action=history&feed=atom&title=AMBP 2026-06-15T10:54:29Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=AMBP&diff=5171&oldid=prev 2021-05-12T13:32:22Z

<p>Новая страница: «Protein AMBP precursor [Contains: Alpha-1-microglobulin (Protein HC) (Alpha-1 microglycoprotein) (Complex-forming glycoprotein heterogeneous in charge); Inter-alp...»</p> <p><b>Новая страница</b></p><div>Protein AMBP precursor [Contains: Alpha-1-microglobulin (Protein HC) (Alpha-1 microglycoprotein) (Complex-forming glycoprotein heterogeneous in charge); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (EDC1) (HI-30) (Uronic-acid-rich protein); Trypstatin] [HCP] [ITIL]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Developmentally regulated transcription of the four liver-specific genes for inter-alpha-inhibitor family in mouse.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/7504460<br /> |abstract=The inter-alpha-inhibitor family is composed of the plasma-protease inhibitors inter-alpha-inhibitor, pre-alpha-inhibitor and bikunin. Inter-alpha-inhibitor and pre-alpha-inhibitor are distinct assemblies of bikunin with distinct sets from three heavy (H) chains designated H1, H2 and H3. These H chains are encoded by a set of three evolutionarily related H genes, and bikunin by an alpha-1-microglobulin/bikunin precursor gene ([[AMBP]]). This precursor is cleaved to yield bikunin, a member of the Kunitz-type protease-inhibitor superfamily, and alpha-1-microglobulin, which belongs to the lipocalin superfamily. Northern-blot experiments with RNAs obtained from various tissues in fetal and in adult mice indicated that the transcription of the four [[AMBP]] and H genes is liver-restricted, although there is expression of H3 in brain. An analysis of the H1, H2, H3 and [[AMBP]] transcripts, as well as of transcripts for other control genes, in liver during development showed a progressive increase in the amounts of the H1, H2, H3 and [[AMBP]] RNAs, which all peak transiently at day 5 after birth. This was shown by a nuclear run-on experiment to originate from a change in transcription rate. The transient and postnatal increase in transcription could be explained neither by the liver-restricted expression nor by a common origin of these four genes, nor by a perinatal requirement for many lipocalins or protease inhibitors. This suggests that all four genes are perinatally triggered at the level of similar elements in their transcriptional regulatory regions, a conclusion strengthened by the weak expression of the four genes that is seen in a mutant mouse strain (albino) that is deficient in some liver-specific transcription factors.<br /> |mesh-terms=* Aging<br /> * Albinism<br /> * Alpha-Globulins<br /> * Animals<br /> * Animals, Newborn<br /> * Female<br /> * Fetus<br /> * Gene Deletion<br /> * Gene Expression Regulation<br /> * Gestational Age<br /> * Glycoproteins<br /> * Humans<br /> * Liver<br /> * Macromolecular Substances<br /> * Male<br /> * Membrane Glycoproteins<br /> * Mice<br /> * Mice, Inbred BALB C<br /> * Mice, Inbred C3H<br /> * Mice, Inbred C57BL<br /> * Mice, Inbred Strains<br /> * Multigene Family<br /> * Protein Precursors<br /> * Rats<br /> * Transcription, Genetic<br /> * Trypsin Inhibitor, Kunitz Soybean<br /> * Trypsin Inhibitors<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1137658<br /> }}</div>

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