https://transhumanist.ru/index.php?action=history&feed=atom&title=ALKBH2 2026-05-12T18:14:20Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ALKBH2&diff=4466&oldid=prev 2021-04-29T19:19:33Z

<p>Новая страница: «DNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Oxy DC1...»</p> <p><b>Новая страница</b></p><div>DNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Oxy DC1) [ABH2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30338756<br /> |abstract=ALKB-8 is a 2-oxoglutarate-dependent dioxygenase homologous to bacterial AlkB, which oxidatively demethylates DNA substrates. The mammalian AlkB family contains AlkB homologues denominated [[ALKBH1]] to 8 and [[FTO]]. The C. elegans genome includes five AlkB-related genes, homologues of [[ALKBH1]], 4, 6, 7, and 8, but lacks homologues of [[ALKBH2]], 3, and 5 and [[FTO]]. [[ALKBH8]] orthologues differ from other AlkB family members by possessing an additional methyltransferase module and an RNA binding N-terminal module. The [[ALKBH8]] methyltransferase domain generates the wobble nucleoside 5-methoxycarbonylmethyluridine from its precursor 5-carboxymethyluridine and its (R)- and (S)-5-methoxycarbonylhydroxymethyluridine hydroxylated forms in tRNA Arg/UCG and tRNA Gly/UCC. The [[ALKBH8]]/ALKB-8 methyltransferase domain is highly similar to yeast TRM9, which selectively modulates translation of mRNAs enriched with [[AGA]] and [[GAA]] codons under both normal and stress conditions. In this report, we studied the role of alkb-8 in C. elegans. We show that downregulation of alkb-8 increases detection of lysosome-related organelles visualized by Nile red in vivo. Reversely, forced expression of alkb-8 strongly decreases the detection of this compartment. In addition, overexpression of alkb-8 applied in a pulse during the L1 larval stage increases the C. elegans lifespan.<br /> |mesh-terms=* Aging<br /> * AlkB Enzymes<br /> * Animals<br /> * Animals, Genetically Modified<br /> * Caenorhabditis elegans<br /> * Caenorhabditis elegans Proteins<br /> * Dioxygenases<br /> * Down-Regulation<br /> * Embryo, Nonmammalian<br /> * Gene Expression Regulation, Developmental<br /> * Green Fluorescent Proteins<br /> * Ketoglutaric Acids<br /> * Larva<br /> * Longevity<br /> * Lysosomes<br /> * Methyltransferases<br /> * Operon<br /> * Promoter Regions, Genetic<br /> * RNA Interference<br /> * S-Adenosylmethionine<br /> <br /> <br /> }}</div>

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