https://transhumanist.ru/index.php?action=history&feed=atom&title=ADRB1 2026-06-23T08:16:16Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ADRB1&diff=5432&oldid=prev 2021-05-12T13:43:46Z

<p>Новая страница: «Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) [ADRB1R] [B1AR] ==Publications== {{medline-entry |title=Common genetic variants of the...»</p> <p><b>Новая страница</b></p><div>Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) [ADRB1R] [B1AR]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23020224<br /> |abstract=β-adrenoceptors are the common pharmacological targets for the treatment of cardiovascular diseases and asthma. Genetic modifications of β-adrenergic system in engineered mice affect their lifespan. Here, we tested whether genes encoding for key components of the β-adrenergic signaling pathway are associated with human longevity. We performed a 10-year follow-up study of the Chinese longitudinal healthy longevity survey. The Han Chinese population in this study consisted of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from [[ADRB1]], [[ADRB2]], [[ADCY5]], [[ADCY6]], and [[MAPK1]] were selected and genotyped. Two SNPs, rs1042718 (C/A) and rs1042719 (G/C), of [[ADRB2]] in linkage disequilibrium (D&#039; = 1.0; r2 = 0.67) were found to be associated with enhanced longevity in men in two geographically isolated populations. Bonferroni-corrected P-values in a combined analysis were 0.00053-0.010. Men with haplotype A-C showed an increased probability to become centenarians (the frequency of A-C in long-lived and young individuals are 0.332 and 0.250, respectively, OR = 1.49, CI 95% = 1.17-1.88, P = 0.0007), in contrast to those with haplotype C-G (the frequency of C-G in long-lived and young individuals are 0.523 and 0.635, respectively, OR = 0.63, CI 95% = 0.51-0.78, P = 0.000018). The permuted P-values were 0.00005 and 0.0009, respectively. [[ADRB2]] encodes the β2-adrenergic receptor; the haplotype A-C markedly reduced its translational efficiency compared with C-G (P = 0.002) in transfected HEK293 cells. Thus, our data indicate that enhanced production of β2-adrenergic receptors caused by genetic variants is inversely associated with human lifespan.<br /> |mesh-terms=* Adenylyl Cyclases<br /> * Aged, 80 and over<br /> * Aging<br /> * Asian Continental Ancestry Group<br /> * Case-Control Studies<br /> * Female<br /> * Follow-Up Studies<br /> * Genes, Reporter<br /> * HEK293 Cells<br /> * Haplotypes<br /> * Humans<br /> * Linkage Disequilibrium<br /> * Longevity<br /> * Luciferases, Renilla<br /> * Male<br /> * Mitogen-Activated Protein Kinase 1<br /> * Polymorphism, Single Nucleotide<br /> * Protein Biosynthesis<br /> * Receptors, Adrenergic, beta-1<br /> * Receptors, Adrenergic, beta-2<br /> * Surveys and Questionnaires<br /> * Transfection<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633790<br /> }}<br /> {{medline-entry<br /> |title=Polymorphism of beta-adrenergic receptors and susceptibility to open-angle glaucoma.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16785856<br /> |abstract=The human trabecular meshwork and ciliary body, which express beta-adrenergic receptors ([[ADRB1]] and [[ADRB2]]), control aqueous humor dynamics. We investigated associations of ADRB polymorphisms with open-angle glaucoma (OAG), because ADRB gene polymorphisms alter receptor function. We studied 240 Japanese controls and 505 Japanese OAG patients including 211 with primary open-angle glaucoma (POAG), and 294 with normal-tension glaucoma (NTG). Associations of four polymorphisms (Ser49Gly and Arg389Gly in the [[ADRB1]] gene; Arg16Gly and Gln27Glu in the [[ADRB2]] gene) were compared between patients and controls. Age, intraocular pressure (IOP), and visual field defects at diagnosis were examined for associations with polymorphisms. The Arg389Gly polymorphism in the [[ADRB1]] gene showed significantly different allele and genotype frequencies in patients with NTG than in controls (p = 0.004 and 0.006, respectively). Other polymorphisms did not show a significant frequency difference. In POAG patients, carriers of Gly16 in the [[ADRB2]] gene were significantly younger at diagnosis than noncarriers (p&lt;0.001). The IOP at diagnosis was significantly higher in OAG patients carrying 27Glu in the [[ADRB2]] gene than in patients without this allele (p&lt;0.001). Clinical characteristics of OAG patients did not differ significantly in relation to other polymorphisms. Certain polymorphisms of the [[ADRB1]] and [[ADRB2]] genes influence the pathophysiology of OAG in Japanese patients.<br /> |mesh-terms=* Aged<br /> * Aging<br /> * Asian Continental Ancestry Group<br /> * Case-Control Studies<br /> * Female<br /> * Gene Frequency<br /> * Genes, Dominant<br /> * Genes, Recessive<br /> * Genetic Predisposition to Disease<br /> * Genotype<br /> * Glaucoma, Open-Angle<br /> * Heterozygote<br /> * Humans<br /> * Intraocular Pressure<br /> * Male<br /> * Middle Aged<br /> * Polymorphism, Genetic<br /> * Polymorphism, Single Nucleotide<br /> * Receptors, Adrenergic, beta-1<br /> * Receptors, Adrenergic, beta-2<br /> <br /> <br /> }}</div>

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